June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Static perimetry over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling
Author Affiliations & Notes
  • Jacque L Duncan
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Jacque Duncan AGTC, DTx Therapeutics, Editas, Eyevensys, Gyroscope, Helios, Nacuity, Spark Therapeutics, SparingVision, ProQR Therapeutics, PYC Therapeutics, Vedere Bio II, Code C (Consultant/Contractor), Acucela, Allergan/Abbvie, Second Sight Medical Products, Biogen/Nightstarx Therapeutics, Neurotech USA, Code F (Financial Support), RxSight, Inc., Code I (Personal Financial Interest)
  • Footnotes
    Support  Foundation Fighting Blindness
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4493 – F0280. doi:
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    • Get Citation

      Jacque L Duncan; Static perimetry over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4493 – F0280.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Static perimetry (SP) provides quantitative measures of peripheral visual field in patients with inherited retinal degenerations (IRDs). There are few available estimates for rates of change in IRDs. Here we provide estimates of change over 2 years in 4 summary measures of SP from the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study using mixed effects models.

Methods : Participants with visual acuity ≥ 20/80, stable fixation, and kinetic visual field of ≥ 10° at baseline in the study eye had full-field static perimetry at baseline, 1, and 2 years. Summary measures were total hill of vision (VTOT), hill of vision in the central 30° (V30), VTOT-V30 (Vperiph), and mean sensitivity. Mixed effects models were used to estimate the annual rates of change and percentage rates of change using log transformed data with 95% confidence intervals. Models were applied to all eyes (N=102) and to a restricted group of eyes with baseline VTOT > 5 dB-sr (N=88) to mitigate floor effects. A model excluding unreliable test results (false positives ≥ 15%) and a model down-weighting outlier rates of change were also applied to the restricted group.

Results : The average decline in VTOT was 2.05 dB-sr/year (Table 1) or 8.3%/year (Table 2) in the entire cohort, but greater at 2.25 dB-sr/year or 8.8%/year in the restricted cohort. The average decline of V30 was 0.48 dB-sr/year or 5.2%/year in the entire cohort versus 0.56 dB-sr/year or 5.9%/year in the restricted cohort. The decline of peripheral visual field (Vperiph) was 1.53 dB-sr/year or 16.0%/year in the entire cohort, and 1.68 dB-sr/year or 13.6%/year in the restricted cohort. The decline rate for mean sensitivity was 0.55 dB/year or 5.1%/year in the entire cohort and 0.60 dB/year or 5.4%/year in the restricted cohort. Excluding unreliable observations or down-weighting outliers reduced the estimated percentage of decline compared to using all eyes in the restricted cohort.

Conclusions : Estimates of the annual rates of decline of static perimetry measures were greater when the study cohort was restricted to eyes with room for worsening. The annual percentage change was greatest in Vperiph after 2 years in eyes with USH2A-related retinal degeneration.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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