June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
High prevalence of polyautoimmunity in patients with uveitis: A cross-sectional study
Author Affiliations & Notes
  • Alejandra de-la-Torre
    Immunology Unit, Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • William Rojas-Carabali
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Carlos Cifuentes-González
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Nicolás Domenico Barraquer
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Diego Polania
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Laura Boada-Robayo
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Daniela Chacón-Zambrano
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • María Alejandra Fonseca-Mora
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Tatiana Muñoz
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Danna Lesley Cruz-Reyes
    Neuroscience Research Group (NEUROS), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogota, Capital District, Colombia
  • Footnotes
    Commercial Relationships   Alejandra de-la-Torre None; William Rojas-Carabali None; Carlos Cifuentes-González None; Nicolás Barraquer None; Diego Polania None; Laura Boada-Robayo None; Daniela Chacón-Zambrano None; María Fonseca-Mora None; Tatiana Muñoz None; Danna Cruz-Reyes None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3924 – A0467. doi:
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      Alejandra de-la-Torre, William Rojas-Carabali, Carlos Cifuentes-González, Nicolás Domenico Barraquer, Diego Polania, Laura Boada-Robayo, Daniela Chacón-Zambrano, María Alejandra Fonseca-Mora, Tatiana Muñoz, Danna Lesley Cruz-Reyes; High prevalence of polyautoimmunity in patients with uveitis: A cross-sectional study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3924 – A0467.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Noninfectious uveitis is highly associated with immune-mediated diseases; however, its association with polyautoimmunity (PolyA) or familial autoimmunity is unknown. Therefore, this study aimed to analyze those phenomena in patients with noninfectious uveitis.

Methods : Cross-sectional study. Means and standard deviations were reported for the quantitative variables and absolute and relative frequencies for qualitative variables. Data were analyzed using hierarchical agglomerative cluster analysis. We first compared the collected variables with the “Index disease” and showed the p-value to find which variables had a statistical relationship to perform the clustering using the Gower coefficient. Then, we performed multivariate analysis and built a multinomial linear regression model. This model had “Index disease” as a dependent variable. The association measure was the β weights obtained. Next, to identify disease co-occurrence patterns to define PolyA spectra in uveitis, the R function “pheatmap” was used; this function allows heat maps to be drawn with the variables most related to PolyA. From the 218 recorded blocks of patients, it produces hard clusters, which were then used to study the co-occurrence of diseases.

Results : We analyzed 218 patients with noninfectious uveitis. Most patients were females (69.3%). The most common clinical characteristics were recurrent course (51.8%), persistent duration (60.6%), and insidious onset (62.4%). Anterior and panuveitis were the most common anatomical locations. Additionally, 36 patients (16.5%) had latent PolyA, and 100 patients (45.9%) had overt PolyA and, of which 22 (10.1%) had Multiple Autoimmune Syndrome. We found 22 index diseases and 28 diseases that coexist grouped in six hard clusters (Fig 1). Patients with PolyA had a mean of 2.3 diseases. One patient had 5 autoimmune diseases together documented. The most common index diseases were Idiopathic uveitis, Autoimmune uveitis, Sjögren’s syndrome, Juvenile idiopathic arthritis, and Ankylosing spondylitis. PolyA was associated statistically with epiretinal membrane (p:0.015) and optic disk edema (p:0.049).

Conclusions : PolyA is a common phenomenon among patients with noninfectious uveitis that can contribute as a risk factor in developing complications.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

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