June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Evaluating Donut-Shaped Hypertransmission Defects on En Face Optical Coherence Tomography in Patients with Age-Related Macular Degeneration
Author Affiliations & Notes
  • Jessica Girgis
    New England Eye Center, Boston, Massachusetts, United States
    Tufts University School of Medicine, Boston, Massachusetts, United States
  • Eric Moult
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Siyu Chen
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Alfredo Gutierrez
    New England Eye Center, Boston, Massachusetts, United States
    Tufts University School of Medicine, Boston, Massachusetts, United States
  • Luísa S.M. Mendonca
    Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • James G Fujimoto
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Nadia K Waheed
    New England Eye Center, Boston, Massachusetts, United States
    Tufts University School of Medicine, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Jessica Girgis None; Eric Moult VISTA-OCTA, Code P (Patent); Siyu Chen None; Alfredo Gutierrez None; Luísa Mendonca Gyroscope Therapeutics , Code C (Consultant/Contractor); James Fujimoto Topcon, Code F (Financial Support), Optovue, Code I (Personal Financial Interest), Optovue, VISTA-OCTA, Code P (Patent); Nadia Waheed Nidek Medical Products, Boehringer Ingelheim, Topcon, Code C (Consultant/Contractor), Gyroscope Therapeutics, Code E (Employment), Carl Zeiss Meditec, Heidelberg, Nidek Medical Products, Topcon, Code F (Financial Support), Ocudyne, Gyroscope Therapeutics , Code I (Personal Financial Interest)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 354 – F0185. doi:
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    • Get Citation

      Jessica Girgis, Eric Moult, Siyu Chen, Alfredo Gutierrez, Luísa S.M. Mendonca, James G Fujimoto, Nadia K Waheed; Evaluating Donut-Shaped Hypertransmission Defects on En Face Optical Coherence Tomography in Patients with Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):354 – F0185.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe and evaluate donut-shaped hypertransmission defects on en face sub-RPE optical coherence tomography (OCT) imaging and the associated findings seen on OCT B-scans in eyes with intermediate and advanced age-related macular degeneration (AMD) using a retrospective, observational study.

Methods : This study included 21 eyes with intermediate or advanced AMD imaged at the New England Eye Center. A donut-shaped hypertransmission defect was defined as a hypertransmission defect surrounding a central area of hypotransmission on en face OCT. Donut-shaped hypertransmission defects on custom en face sub-RPE slabs and their associated B-scans were acquired using a 3 µm, 128 kHz A-scan rate ultrahigh resolution spectral-domain OCT (UHR SD-OCT) and/or commercial SD-OCT devices.

Results : A total of 40 donut-shaped hypertransmission defects from 21 patients were identified on en face OCT. The donut-shaped hypertransmission defects were found to be associated with RPE migration, drusen with heterogenous or non-reflective homogenous contents, incomplete retinal pigment epithelium and outer retinal atrophy (iRORA), and/or complete retinal pigment epithelium and outer retinal atrophy (cRORA) on associated commercial and UHR SD-OCT B-scans. In each case, the hypertransmission on en face OCT corresponded to choroidal hypertransmission secondary to RPE disruption on associated B-scans. In 9 lesions, a clump of preserved RPE in the center of iRORA or cRORA lesions was observed with associated relative hypotransmission into the choroid, as seen in Figure 1; this area of preserved RPE corresponded to the central area of hypotransmission on en face OCT.

Conclusions : Donut-shaped hypertransmission defects on en face OCT sub-RPE slabs were evaluated and found to be associated with various findings on SD-OCT B-scans, including RPE migration, drusen with homogenous or heterogenous contents, iRORA, and/or cRORA. Future longitudinal studies may be performed to determine if the presence of donut-shaped lesions is associated with faster progression to advanced AMD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1: A donut-shaped hypertransmission defect identified on en face commercial SD-OCT sub-RPE slab (A) with its associated commercial SD-OCT B-scan (B) and UHR SD-OCT B-scan (C). The arrows in Figure 1B and 1C highlight an area of iRORA with a preserved central RPE clump.

Figure 1: A donut-shaped hypertransmission defect identified on en face commercial SD-OCT sub-RPE slab (A) with its associated commercial SD-OCT B-scan (B) and UHR SD-OCT B-scan (C). The arrows in Figure 1B and 1C highlight an area of iRORA with a preserved central RPE clump.

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