June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Evaluating an OCT-based grading of age-related macular degeneration severity from The Northern Ireland Sensory Aging studies using measurement of dark adaptation
Author Affiliations & Notes
  • Bethany Elora Higgins
    Optometry and Vision Sciences, City University of London, London, London, United Kingdom
  • Giovanni Montesano
    Optometry and Vision Sciences, City University of London, London, London, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Timos Naskas
    Queen's University Belfast, Belfast, United Kingdom
  • Katie Graham
    Queen's University Belfast, Belfast, United Kingdom
  • Usha Chakravarthy
    Queen's University Belfast, Belfast, United Kingdom
  • Frank Kee
    Queen's University Belfast, Belfast, United Kingdom
  • David Wright
    Queen's University Belfast, Belfast, United Kingdom
  • Ruth E. Hogg
    Queen's University Belfast, Belfast, United Kingdom
  • David P. Crabb
    Optometry and Vision Sciences, City University of London, London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Bethany Higgins None; Giovanni Montesano Centervue, Ivantis, Omikron, Code C (Consultant/Contractor); Timos Naskas None; Katie Graham None; Usha Chakravarthy Roche, Code E (Employment), Bayer, Code F (Financial Support); Frank Kee None; David Wright None; Ruth Hogg Optos Plc, Novartis, Code F (Financial Support); David Crabb Centervue, Apellis, Allergan, Thea, Roche, Code C (Consultant/Contractor), Apellis, Santen, Allergan, Centervue, Code F (Financial Support), Santen, Allergan, Thea, Code R (Recipient), Santen, Medisoft, Code S (non-remunerative)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3340 – F0149. doi:
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      Bethany Elora Higgins, Giovanni Montesano, Timos Naskas, Katie Graham, Usha Chakravarthy, Frank Kee, David Wright, Ruth E. Hogg, David P. Crabb; Evaluating an OCT-based grading of age-related macular degeneration severity from The Northern Ireland Sensory Aging studies using measurement of dark adaptation. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3340 – F0149.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Studies suggest delayed rod-mediated dark adaptation (DA) is a diagnostic indicator of age-related macular degeneration (AMD). We assessed if DA differences (estimated by rod-intercept time [RIT]) are more discernible between AMD severity grades using an OCT-based criteria (including subretinal drusenoid deposit [SDD] presence) over a Colour Fundus Photography (CFP)-based classification.

Methods : Data was acquired from two related cross-sectional population based studies - Northern Ireland Sensory Aging studies (NISA;NISA-2). Participants with RIT data (AdaptDx [Maculogix,USA]) and both CFP (Canon CX-1 Digital Fundus Camera [Canon,USA]) and spectral domain OCT (SD-OCT;Heidelberg Spectralis SD-OCT [Heidelberg Engineering, Germany]) images were used. SDD presence was identified and images graded by Beckman and OCT-based classifications. Age-corrected time-to-event analysis assessed the magnitude of differences in RIT and plotted using Kaplan Meier curves (Fig 1).

Results : 459 eyes (mean [standard deviation; SD] age 66[8] years) were stratified into Beckman0-3 and then OCT0-2. Uncorrected mean(SD) RIT for Beckman groups was 7.5(5.3), 8.0(4.3), 7.3(4.7) and 15.6(11.9) mins, respectively. Uncorrected mean(SD) RIT for OCT groups appeared more distinct between gradings: 7.4(5.5), 10.0(7.2) and 15.3(21.0) mins respectively. After age-correcting, eyes in B3 had statistically significantly worse average RITs compared to the other groups (B0-2; p=<0.005 all) but there were no differences in RIT between the other Beckman groups. Eyes in OCT2 had worse RITs compared to controls (OCT0) (p=<0.001) and eyes in OCT1 (p=0.009). No statistically significant difference was found between OCT0 and OCT1 (p=0.195). SDD presence significantly worsened RIT within OCT2 (p=0.002) but not within OCT1 (p=0.285). In OCT0 the presence of SDDs gave better RIT values(p=0.012).

Conclusions : There is some evidence of differences in RIT being more apparent between AMD severity grades using an OCT-based rather than a CFP-based classification, but differences were less clear once corrected for age. OCT classifications including SDDs, may be useful for clinical trials in AMD. A highlight of our enriched population study is a uniquely large SDD sample (n=109) not regularly reported in recent DA research.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Fig 1.Survival curves of RIT stratified by Beckman and OCT grading

Fig 1.Survival curves of RIT stratified by Beckman and OCT grading

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