June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Assessing the Relationship of Exfoliation Syndrome and Abdominal Aortic Aneurysm: A Large Database Study
Author Affiliations & Notes
  • Matthew Esplin Conley
    The University of Utah School of Medicine, Salt Lake City, Utah, United States
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Ayesha Patil
    The University of Utah School of Medicine, Salt Lake City, Utah, United States
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Christian J Pompoco
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Chase Paulson
    The University of Utah School of Medicine, Salt Lake City, Utah, United States
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Samuel C Taylor
    The University of Utah School of Medicine, Salt Lake City, Utah, United States
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Cole J Swiston
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Jennifer Herrick
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Robert Ritch
    New York Eye and Ear Infirmary, Mount Sinai Health System, New York, New York, United States
  • Karen Curtin
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Barbara M Wirostko
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
  • Footnotes
    Commercial Relationships   Matthew Conley None; Ayesha Patil None; Christian Pompoco None; Chase Paulson None; Samuel Taylor None; Cole Swiston None; Jennifer Herrick None; Robert Ritch None; Karen Curtin None; Barbara Wirostko None
  • Footnotes
    Support  National Glaucoma Program of the BrightFocus® Foundation Award G2020317
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1649 – A0144. doi:
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    • Get Citation

      Matthew Esplin Conley, Ayesha Patil, Christian J Pompoco, Chase Paulson, Samuel C Taylor, Cole J Swiston, Jennifer Herrick, Robert Ritch, Karen Curtin, Barbara M Wirostko; Assessing the Relationship of Exfoliation Syndrome and Abdominal Aortic Aneurysm: A Large Database Study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1649 – A0144.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Controversy exists concerning the possible association of exfoliation syndrome and abdominal aortic aneurysms due to conflicting evidence in prior studies. A retrospective, electronic medical records (EMR) study was performed using the statewide Utah Population Database (UPDB) to investigate the relationship of exfoliation syndrome and exfoliation glaucoma (XFS/XFG) in abdominal aortic aneurysm (AAA) patients.

Methods : A population-based, retrospective study was undertaken using the Utah Population Database (UPDB). Patients ages ≥40y identified with an AAA diagnosis from 1996-2015, based on International Classification of Diseases (ICD) version 9/10 codes, were included (n=7167). An XFS/XFG outcome in AAA patients and in 5:1 sex- and age-matched controls (n=35,923) was determined from a patient population identified with XFS/XFG (n=3,582) based on ICD 9/10 codes. A hazards model with a competing risk of death was used to determine the risk of XFS/XFG in AAA patients compared with controls. A chart review was conducted to confirm a clinical diagnosis of AAA in XFS/XFG patients.

Results : Of AAA patients, 20 (0.3%) developed XFS/XFG, while in controls, 118 (0.3%) developed XFS/XFG. We found no increased risk of XFS/XFG in AAA patients compared with controls (HR=0.99, 95%CI 0.6-1.6). Of the XFS/XFG patient cohort, 9 patients had a clinical diagnosis of AAA (0.3%) upon chart review. Of chart-review patients confirmed to have both conditions, 50% were male and, on average, had: AAA presentation at age 76y; initial AAA size, 3.9 cm; and XFS/XFG presentation age, 77y.

Conclusions : Exfoliation syndrome is a multifactorial, age-related systemic disorder with genetic and environmental influences associated with various clinical comorbidities. Although prior studies have shown a relationship between XFS and AAA, these findings, from a large UPDB investigation, do not support an association between AAA and the development of XFS/XFG.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Table 1a. Definition of Abdominal Aortic Aneurysm
Table 1b. Definition of Exfoliation Syndrome and Exfoliation Glaucoma
Abbreviations: ICD-9/10, International Classification of Diseases, Ninth Revision, and Tenth Revision respectively

Table 1a. Definition of Abdominal Aortic Aneurysm
Table 1b. Definition of Exfoliation Syndrome and Exfoliation Glaucoma
Abbreviations: ICD-9/10, International Classification of Diseases, Ninth Revision, and Tenth Revision respectively

 

Table 2
Characteristics of abdominal aortic aneurysm (AAA) and exfoliation syndrome/exfoliation (XFS/XFG) cohorts

Table 2
Characteristics of abdominal aortic aneurysm (AAA) and exfoliation syndrome/exfoliation (XFS/XFG) cohorts

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