Abstract
Purpose :
Selective laser trabeculoplasty (SLT) is a procedure used as a therapy option in glaucoma to lower intraocular pressure (IOP). Currently, there is limited data on statistically significant IOP effects of SLT in pseudophakic eyes vs phakic eyes.1,2,3 This study investigates the postoperative change in IOP in phakic vs pseudophakic eyes with glaucoma.
Methods :
This is a retrospective observational study on patients who visited George Washington University Department of Ophthalmology from January 1, 2015 to January 1, 2019 with primary open-angle, pseudoexfoliation, pigmentary, or normal-tension glaucoma and received 360 degrees SLT. Patients were excluded if they had laser or glaucoma surgery either 6 months prior to or 12 months following SLT, other glaucoma types, or used steroids. Demographics were collected and the pre- vs post-SLT IOP were analyzed using Wilcoxon signed rank test.
Results :
160 patients (N=103 African American, 64%, N=37 Caucasian, 23%, N=7 Asian, 4%, N=6 Hispanic or Latino, 4%, N=6 Other, 4%) were included in this study. Mean IOPs for phakic and pseudophakic eyes were collected at baseline, 6-week, 6-month, and 12-month visits (Table 1). P-values comparing interval mean IOP points to the baseline IOP and were found to be significant (P<0.05) for phakic and pseudophakic groups. P-values comparing mean IOP between phakic and pseudophakic eyes at baseline, 6-week, 6-month, and 12-month are listed in Table 1.
Conclusions :
Our study not only includes a larger study group of 160 patients, but also a novel analysis of a diverse demographic population (64% African American) compared to other studies with an average of 50 participants and exclusively focused on Caucasian populations. Previous history of cataract surgery does not negatively impact decrease in mean IOP 6 weeks, 6 months, and 12 months post-SLT. However, our results are consistent with previous studies in showing no significant IOP reduction between phakic and pseudophakic eyes post-SLT. Further investigation with a diverse population is required to comprehensively understand the correlation between pseudophakia and IOP reduction post-SLT.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.