June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Intraocular Pressure Measurement in Childhood Glaucoma under Standardized General Anaesthesia - the Prospective EyeBIS Study
Author Affiliations & Notes
  • Alicja Strzalkowska
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Justus Buse
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Nina Pirlich
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Julia Stingl
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Alexander Schuster
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Jasmin Rezapour
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Felix Wagner
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Esther M Hoffmann
    Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Footnotes
    Commercial Relationships   Alicja Strzalkowska None; Justus Buse None; Nina Pirlich None; Julia Stingl None; Alexander Schuster None; Jasmin Rezapour None; Felix Wagner None; Esther Hoffmann None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 156 – A0349. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alicja Strzalkowska, Justus Buse, Nina Pirlich, Julia Stingl, Alexander Schuster, Jasmin Rezapour, Felix Wagner, Esther M Hoffmann; Intraocular Pressure Measurement in Childhood Glaucoma under Standardized General Anaesthesia - the Prospective EyeBIS Study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):156 – A0349.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare intraocular pressure (IOP) measurements using iCare® PRO rebound tonometry (iCare) and Perkins applanation tonometry (Perkins) in childhood glaucoma suspects and healthy children under protocol-defined general anaesthesia (GA).

Methods : A prospective clinical, case-control study of children who underwent an ophthalmologic examination under GA according to our Childhood Glaucoma Center protocol between April 2019 and March 2021. IOP was taken three times (T1-T3) according to the depth of GA, measured with bispectral index (BIS), which is a continuous form of complex processed electroencephalogram (EEG). IOP measurment was taken three times, alternating, starting with iCare: T1 iCare-Perkins, T2 iCare-Perkins, T3 iCare-Perkins, see Figure 1. Central corneal thickness (CCT) was measured before IOP measurement. Correlation between iCare and Perkins was analysed at each measurement point. CCT was taken into account.

Results : 150 eyes of 75 children were included: 53 glaucoma suspects and 22 healthy controls. Children were 45.45 ± 29.76 months old [mean ± SD]. 54.05% of all children were female. Glaucoma suspects: IOP measured with iCare was 26.8±11.2, 23.2±11.4, 21.7±10.3mmHg and Perkins 18.2±7.7, 16.0±7.1, 16.1±7.4mmHg [mean ± SD] at T1, T2, T3, see Figure 2.
Healthy controls: 14.3±4.7; 10.5±2.5; 10.1±3.0mmHg and 10.2±3.1; 7.4±3.0; 6.9±2.5mmHg, respectively [mean ± SD]. The correlation between iCare and Perkins was good: the intraclass correlation coefficient (r) between the two methods was 0.629 (p<0.001). The mean IOP is statistically significantly higher with iCare than with Perkins (p<0.001) in both groups. The mean difference (iCare and Perkins) was 6.0±6.1mmHg.
Correlation between IOP and CCT was not statistically significant in both groups.

Conclusions : The IOP were higher in glaucoma subjects than in the healthy ones. iCare leads to higher IOP compared to Perkins in standardized anaesthesia in children. The IOP changes during the course of anesthesia and should be measured at the beginning of anaesthesia according to our protocol, because at this point the IOP is the highest. In our study, IOP was independent of CCT.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1. Sequence of measurements

Figure 1. Sequence of measurements

 

Figure 2. Median IOP at T1-T3 measured with iCare and Perkins a) glaucoma suspect b) healthy children measured

Figure 2. Median IOP at T1-T3 measured with iCare and Perkins a) glaucoma suspect b) healthy children measured

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×