Abstract
Purpose :
The recent 24-2C SITA Faster visual field (VF) test increases sensitivity of central field defects by adding 10 test locations from the 10-2 pattern to the end of the 24-2 test. However, some clinicians prefer to test glaucoma patients with the SITA Standard strategy. The purpose of this ongoing clinical study was to compare the 24-2C SITA Standard to the 24-2C SITA Faster in healthy and glaucomatous eyes.
Methods :
24-2C SITA Standard (SS) and 24-2C SITA Faster (SFR), as well as 10-2 SS, and 10-2 SITA Fast VFs were acquired on an HFA3 Model 860 perimeter (ZEISS, Dublin, CA) at each of two visits on one eye for healthy and glaucomatous subjects. 24-2 SS VFs were extracted from 24-2C SS as a reference for disease severity. Data from last qualified visit were used for analyses; 10-2 VFs were not used for these analyses.
Bland-Altman and scatter plots were used to assess agreement for the Mean Deviation (MD), Visual Field Index (VFI), and Pattern Standard Deviation (PSD) global parameters. The sum of any total deviation (TD) and pattern deviation (PD) points flagged for the VFs were totaled and compared using paired equivalence t-tests (α = 0.05). Limits of equivalence were chosen as 5% of total test points.
Results :
Mean age was 57.3 (standard deviation, SD: 7.6; range: 44.3 to 74.7) years for 28 healthy eyes and 71.3 (SD: 9.0; range 54.0 to 97.9) years for 28 glaucoma eyes. Mean 24-2 SS MD was 0.38 (SD: 1.17; range: -1.89 to 2.62) dB and -7.92 (SD: 7.72; range: -23.42 to 1.63) dB in healthy and glaucoma eyes, respectively.
MD, VFI, and PSD values were similar between both strategies across all eyes, with linear correlations ranging from 0.98 to 0.99 (See Fig. 1). For healthy eyes, mean difference (SD) for TD was -0.9 (SD: 3.9) points and 1.1 (5.1) points for PD while glaucoma mean difference was -0.1 (8.8) for TD and 1.2 (5.9) points for PD (see Table 1).
Conclusions :
24-2C SITA Standard showed comparable sensitivity to detect visual field defects as 24-2C SITA Faster in this study, with mean differences between the number of any flagged TD and PD points ranging from -0.9 to 1.2 defects. Thus, the 24-2C test pattern with the reference SITA Standard strategy may offer clinicians a similar ability to detect central visual field loss as SITA Faster without the need to run a supplementary SITA 10-2.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.