June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Comparison of OCT retinal layer properties in normal and early AMD in the Alabama study on early age-related macular degeneration 2 (ALSTAR2)
Author Affiliations & Notes
  • Chaiyaporn C Vatanatham
    Doheny Eye Institute, Los Angeles, California, United States
  • Ziyuan Wang
    Doheny Eye Institute, Los Angeles, California, United States
  • Zubin Mishra
    Doheny Eye Institute, Los Angeles, California, United States
  • Sohaib Fasih-Ahmad
    Doheny Eye Institute, Los Angeles, California, United States
  • Anjal Jain
    Doheny Eye Institute, Los Angeles, California, United States
  • Anushika Ganegoda
    Doheny Eye Institute, Los Angeles, California, United States
  • Zhihong Hu
    Doheny Eye Institute, Los Angeles, California, United States
  • Mark Clark
    The University of Alabama at Birmingham Department of Ophthalmology and Visual Sciences, Birmingham, Alabama, United States
  • Cynthia Owsley
    The University of Alabama at Birmingham Department of Ophthalmology and Visual Sciences, Birmingham, Alabama, United States
  • Christine A Curcio
    The University of Alabama at Birmingham Department of Ophthalmology and Visual Sciences, Birmingham, Alabama, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Chaiyaporn Vatanatham None; Ziyuan Wang None; Zubin Mishra None; Sohaib Fasih-Ahmad None; Anjal Jain None; Anushika Ganegoda None; Zhihong Hu None; Mark Clark None; Cynthia Owsley NEI, R01EY029595, Code F (Financial Support); Christine Curcio NEI, R01EY029595, Code F (Financial Support), NIH, R01EY027948, Code F (Financial Support), Genentech/Hoffman LaRoche, Code F (Financial Support), Regeneron, Code F (Financial Support), MacRegen Inc., Code I (Personal Financial Interest); Srinivas Sadda Amgen, Allergan, Genentech/Roche, Iveric, Oxurion, Novartis, Regeneron, Bayer, 4DMT, Centervue, Heidelberg, Optos, Merck, Apellis, Astellas, Code C (Consultant/Contractor), Carl Zeiss Meditec, Nidek, Code R (Recipient), Nidek, topcon, Heidelberg, Carl Zeiss Meditec, Optos, Centervue, Code R (Recipient)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1042 – F0289. doi:
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    • Get Citation

      Chaiyaporn C Vatanatham, Ziyuan Wang, Zubin Mishra, Sohaib Fasih-Ahmad, Anjal Jain, Anushika Ganegoda, Zhihong Hu, Mark Clark, Cynthia Owsley, Christine A Curcio, Srinivas R Sadda; Comparison of OCT retinal layer properties in normal and early AMD in the Alabama study on early age-related macular degeneration 2 (ALSTAR2). Invest. Ophthalmol. Vis. Sci. 2022;63(7):1042 – F0289.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : While drusen and subretinal drusenoid deposits (SDD) are commonly associated with the initial diagnosis of age-related macular degeneration (AMD), early AMD patients are known to have scotopic deficits and presumed photoreceptor alterations. In this study, we sought to better characterize the structural alterations associated with the transition from normal aging to early AMD by quantifying the outer retinal layers on optical coherence tomography (OCT) volumes.

Methods : Subjects ≥ 60 years with either normal macular health (AREDS 1) or early AMD (AREDS 2-4) were enrolled as part of the Alabama Study on Early Age-related Macular Degeneration 2 (ALSTAR2). Eye-tracked SD-OCT macular volumes (1 per participant) were acquired with a Spectralis HRA + OCT2. A novel deep-learning-derived graph-based algorithm was used to segment 6 outer retinal layers (photoreceptor inner segment (inner segment myoid defined as external limiting membrane-ellipsoid zone (EZ) center line), photoreceptor outer segment (EZ center line-interdigitation zone outer surface), SDD, retinal pigment epithelium (RPE), drusen, choroid), and segmentation errors were manually corrected (fig. 1). Retinal layer mean thickness within 9 ETDRS subfields was computed and compared between the groups.

Results : The study cohort included 400 eyes: 140 early AMD and 260 normal. Table 1 shows comparison of mean thickness between normal and early AMD. In early AMD, increased mean thickness of drusen was observed in most subfields. SDD were numerically thicker in all subfields, but statistically significant in only a few. In contrast, the photoreceptor inner and outer segments were numerically thinner in all subfields but not statistically significant. No significant differences were observed in the RPE or choroid layer.

Conclusions : In the transition from normal to early AMD, drusen thickness increases consistently throughout the macula. SDD thickness increases in some subfields. The bacillary layer was thinner in early AMD, but the difference was not statistically significant. The choroid layer showed no difference in thickness in any subfield.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Fig. 1. Ex. B-scan segmentation

Fig. 1. Ex. B-scan segmentation

 

Note: * p<.05
** p<.01
Positive mean difference indicates increased mean thickness of early AMD compared to normal

Table 1. Mean thickness (μm) comparison of 6 outer retinal layers between normal and early AMD in 9 ETDRS subfields

Note: * p<.05
** p<.01
Positive mean difference indicates increased mean thickness of early AMD compared to normal

Table 1. Mean thickness (μm) comparison of 6 outer retinal layers between normal and early AMD in 9 ETDRS subfields

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