June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Prevalence of Cardiac Sarcoidosis in Patients with Ocular Sarcoidosis
Author Affiliations & Notes
  • Ryan Anderson
    University of Louisville School of Medicine, Louisville, Kentucky, United States
  • Emma Hawkins
    Medical University of South Carolina College of Medicine, Charleston, South Carolina, United States
  • Joshua Van Swol
    Medical University of South Carolina College of Medicine, Charleston, South Carolina, United States
  • Ethan Joseph
    Medical University of South Carolina College of Medicine, Charleston, South Carolina, United States
  • Wei Wang
    Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, United States
  • Lynn Perry
    Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, United States
  • Harpal Amarjeet SIngh Sandhu
    Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, United States
  • Footnotes
    Commercial Relationships   Ryan Anderson None; Emma Hawkins None; Joshua Van Swol None; Ethan Joseph None; Wei Wang None; Lynn Perry None; Harpal Sandhu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3926 – A0469. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ryan Anderson, Emma Hawkins, Joshua Van Swol, Ethan Joseph, Wei Wang, Lynn Perry, Harpal Amarjeet SIngh Sandhu; Prevalence of Cardiac Sarcoidosis in Patients with Ocular Sarcoidosis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3926 – A0469.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Some uveitis specialists eschew further differentiation of non-infectious uveitis, even though specific uveitic syndromes may have consequences for systemic health. Sarcoidosis is a multisystem inflammatory disease that is a regionally common cause of non-infectious ocular inflammation. The objective of this study was to determine the prevalence and manifestations of cardiac sarcoidosis in patients with ocular sarcoidosis.

Methods : This was a retrospective cohort study of patients diagnosed with ocular sarcoidosis as defined by the International Workshop on Ocular Sarcoidosis (IWOS) at the University of Louisville from 2017-2020 and the Medical University of South Carolina from 2005-2020. Medical records were first searched for at least a suspected diagnosis of sarcoidosis, then for ocular manifestations of sarcoidosis, and finally for an electrocardiogram (EKG). Patients lacking any of these three components were excluded. Cardiac past medical histories and EKG findings consistent with a sarcoidosis diagnosis were also obtained, including ventricular arrythmias, heart blocks, and paroxysmal ventricular contractions.

Results : Of the 232 patients with sarcoid uveitis, 20 (8.6%) had known cardiac involvement at the time of ocular diagnosis. Sixteen patients (6.9%) had EKG abnormalities consistent with cardiac sarcoidosis. Eight patients had known histories of cardiac sarcoidosis and three had confounding cardiac histories that explained their EKG findings, leaving five patients (2.2%) with ocular sarcoidosis whose cardiac disease was only identified after a diagnosis of possible, probable, presumed, or definite ocular sarcoidosis had been made. Four patients with relevant EKG findings had this study done within 6 months of their diagnosis of sarcoidosis.

Conclusions : Nearly 10% of patients with ocular sarcoidosis have manifestations of cardiac sarcoidosis, some of whom were diagnosed only after presentation to an ophthalmologist with uveitis. Our results suggest that EKG is a reasonable test to include for patients with signs of ocular sarcoidosis to screen for cardiac issues, which are potentially life-threatening. This work suggests that further differentiation of non-infectious uveitis can have important implications for systemic health. Further research is needed to see if EKG abnormalities can be detected before other cardiac manifestations in this patient population.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×