June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Combined Umbilical cord patching with amniotic membrane graft for corneal reconstruction
Author Affiliations & Notes
  • karim Elmowafi
    ophtalmology, Mansoura University Faculty of Medicine, Mansoura, Egypt
  • Rania kamel
    ophtalmology, Mansoura University Faculty of Medicine, Mansoura, Egypt
  • Sahar El Tarshoby
    ophtalmology, Mansoura University Faculty of Medicine, Mansoura, Egypt
  • Footnotes
    Commercial Relationships   karim Elmowafi None; Rania kamel None; Sahar El Tarshoby None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3486. doi:
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      karim Elmowafi, Rania kamel, Sahar El Tarshoby; Combined Umbilical cord patching with amniotic membrane graft for corneal reconstruction. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3486.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study is Evaluation role of umbilical cord patch transplantation for corneal perforations and descemetoceles by assessment of healing of corneal perforation and increased corneal thickness in case with descemetoceles by using slit lamp bio microscopy and anterior segment optical coherence tomography.

Methods : After topical anesthesia for cases with corneal thinning patients and general anesthesia in corneal perforation cases. the base and surrounding of the ulcers were cleaned of necrotic tissue. The Umbilical cord patching with epithelium side facing up was trimmed to fit the shape and depth of the ulcer, and interrupted sutures were placed to anchor the UCP to the cornea. A large piece of the amniotic membrane with epithelium side up was applied over the entire cornea. Finally, bandage contact lens was applied. All patients were followed up daily throughout the first week, weekly for 1 month, then monthly for the first 6 months.

Results : There were 20 eyes with Corneal perforation or thinning. The diameter of corneal thinning ulcers of 3.5±2. 5mm.The anterior chamber in all 20 eyes formed at first postoperative day with improvement of preoperative photophobia foreign body sensation. The corneal thickness was increased in cases with corneal thinning from mean 86.00 ± 24μm to 194± 25μm postoperatively. Healing of corneal defect of cases with corneal perforation at average of 4 weeks. Best Correction Visual acuity in cases with thinning improvement from (-1.82 ± 3.455) by Log MAR to (-0.66 ± 1.942). While, cases with perforation there was an improvement from (-0.53 ± 0.548) to (0.79 ± 0.677)

Conclusions : The current study demonstrated the promising effects of combining UCP with amniotic membrane transplantation is a promising alternative for corneal insult, providing satisfactory reconstruction. Because of its stem cell therapy plus easy availability and efficacy .

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

female 55 years old presented by descemetocele and visal acuity was hand motion , After first , second and third postoperative follow up the conreal thickness have been increased in the first ten days from 72 to 94 and her vision improved gradually till it reach 0.1

female 55 years old presented by descemetocele and visal acuity was hand motion , After first , second and third postoperative follow up the conreal thickness have been increased in the first ten days from 72 to 94 and her vision improved gradually till it reach 0.1

 

14 years old girl , presented by neglected corneal ulcer with perforation and iris prolase , her vision was hand motion and postoperative have been jump to 0.7 with -2 cylindar in that axis

14 years old girl , presented by neglected corneal ulcer with perforation and iris prolase , her vision was hand motion and postoperative have been jump to 0.7 with -2 cylindar in that axis

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