Abstract
Purpose :
To describe the macular optical coherence tomography findings in eyes of patients with congenital nystagmus syndrome compared to healthy subjects.
Methods :
In this comparative cross-sectional observational study, a spectral-domain optical coherence tomography was conducted on eyes of congenital nystagmus syndrome patients and compared with those of healthy individuals (control group). ETDRS macular map was used in the analysis and average thickness of central 6mm (C6T), average thickness of central 1mm (C1T) and thinnest central thickness (CRT) were obtained and compared between the groups. Prevalence and grading of foveal hypoplasia and albinism were assessed in the patients group.
Results :
46 eyes of 23 congenital nystagmus syndrome patients and 46 eyes of 23 healthy individuals were included in the study. 80% of the eyes in nystagmus group had foveal hypoplasia. The mean grade of foveal hypoplasia is 3.45 ±0.9323 in the above group. 40% of patients with nystagmus had either ocular albinism or oculocutaneous albinism. CRT was 258.2 ± 48.31 µm in the nystagmus group compared to 189.3 ± 24.25 µm in the control group with a mean difference of 68.85 ± 7.97 µm (P<0.001). C1T was 267.2 ± 36.01 µm in the nystagmus group compared to 231.0 ± 26.0 µm in the control group with a mean difference of 36.20 ± 6.548 (P<0.001). C6T was 256.2 ± 26.15 µm in the nystagmus group compared to 279.1 ± 9.532 µm in the control group with a mean difference of -22.90 ± 4.104 µm (P<0.001).
Conclusions :
The results of this study show that the majority of congenital nystagmus syndrome patients have foveal hypoplasia. Macular optical coherence tomography can be used to assess the foveal thickness and grading of foveal hypoplasia patients with nystagmus.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.