Endothelial morphometric characteristics in primary cornea guttata.

Abstract

Purpose : To describe the morphology of the corneal endothelium in healthy Hispanic patients with primary cornea guttata (PCG).

Methods : A retrospective, descriptive, and analytical study of specular microscopies was performed to study the central region of the corneal endothelium in healthy, surgery-naive Hispanic patients with PCG.

Results : 123 eyes from 76 patients with PCG were included for analysis. Mean age was 68.14 ± 10.55 years (range 45-88 years). Mean cell density (MCD) 1853.10±643 cells/mm2, the mean cell area was 596.1±263 µm2, and the mean central corneal thickness was 527.55±47.56 µm. 65% of patients had polymegethism and 80.5% had pleomorphism. 84% of patients had less than 25% total area affected. Females were the majority of PCG patients (64%), with higher rates of polymegethism (58.6%), and pleomorphism (63.6%).

Conclusions :
Hispanic patients with PCG show a lower than average MCD compared to the Hispanic population. A high rate of polymegethism and pleomorphism was observed, particularly in females, where PCG was more frequent.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Grading of cornea guttata as observed in specular microscopy. Grade 1 represents 0% total affected area but with visible guttae in slit-lamp. Grade 2 represents a <10% area, grade 3 10-25% area, grade 4 25-50% area , and grade 5 > 50% total affected area (left to right).