June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Prevalence and Risk Factors of Macular Retinoschisis in highly myopic eyes: the Beijing Eye Study 2011
Author Affiliations & Notes
  • Zhe Pan
    Beijing Tongren Eye Center, Beijing, China
  • Ya Xing Wang
    Beijing Tongren Eye Center, Beijing, China
  • Chun Zhang
    Peking University Eye Center, Beijing, China
  • Footnotes
    Commercial Relationships   Zhe Pan None; Ya Xing Wang None; Chun Zhang None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 263 – A0117. doi:
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      Zhe Pan, Ya Xing Wang, Chun Zhang; Prevalence and Risk Factors of Macular Retinoschisis in highly myopic eyes: the Beijing Eye Study 2011. Invest. Ophthalmol. Vis. Sci. 2022;63(7):263 – A0117.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the prevalence and risk factors of macular retinoschisis (MRS) in highly myopic eyes and their morphological features observed by optical coherence tomography (OCT) in Chinese population.

Methods : The population-based Beijing Eye Study 2011enrolled 3468 participants (1963 women, 56.6%) with a mean age of 64.6 ± 9.8 years (50 - 93). Spectral-domain OCT was applied in every participant, including the macula cube scan of 30× 25°centered in the fovea. High myopia was defined as a refractive error ≤ -6 diopters or an axial length ≥ 26.0 mm. MRS were detected by OCT images.

Results : A total of 213 highly myopic eyes of 129 participants were analyzed, with a mean refractive error of -8.5 ± 3.2 diopter, or a mean axial length 26.8 ± 1.4 mm. MRS was found in 36 subjects (48 eyes) with a prevalence of 27.9% (95% confidence interval (CI): 20.5%, 35.7%) per subject or 22.5% (95%CI: 16.9%, 28.6%) per eye. MRS was observed most frequently in the extrafoveal region (15 eyes, 65.2%), as compared with other locations, including 3 eyes in the foveal only region (13.0%), 2 eyes in the fovea plus part of parafoveal region (8.7%) and 3 eyes in the entire macular region (13.0%). The presence of MRS was more often seen in participants of a higher body weight (P=0.014), with more myopic refraction (P<0.001; OR, 0.75; 95%CI, 0.64, 0.88) (Figure 1), with a higher intraocular pressure (P=0.013), and with a wider parapapillary gamma zone (P=0.004), after multivariate analysis.

Conclusions : The prevalence of MRS was 27.9% in highly myopic participants in an older Chinese population. Body weight, intraocular pressure and gamma zone width may play a role in the development of MRS, besides the effect of myopic refraction.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

the Prevalence of Macular Retinoschisis in Different Spherical Equivalence

the Prevalence of Macular Retinoschisis in Different Spherical Equivalence

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