June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Interocular retinal nerve fiber layer thickness in Parkinson disease
Author Affiliations & Notes
  • Mariana Nadais Aidar
    Ophthalmology, Iamspe, Sao Paulo, São Paulo, Brazil
  • Camila Matsuura Endo
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Patrick Israel Fligelman Kanas
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Lisângela Morimoto
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Diovani Costa Madeira
    Ophthalmology, Iamspe, Sao Paulo, São Paulo, Brazil
  • Yasmin Tournier Boppre
    Ophthalmology, Iamspe, Sao Paulo, São Paulo, Brazil
  • Andrea Cotait Kara-José
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Henrique Ballalai Ferraz
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Roberta Arb Saba
    Ophthalmology, Iamspe, Sao Paulo, São Paulo, Brazil
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Eric Pinheiro Andrade
    Ophthalmology, Iamspe, Sao Paulo, São Paulo, Brazil
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Ivan Maynart Tavares
    Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships   Mariana Aidar None; Camila Endo None; Patrick Kanas None; Lisângela Morimoto None; Diovani Madeira None; Yasmin Boppre None; Andrea Kara-José None; Henrique Ferraz None; Roberta Saba None; Eric Andrade None; Ivan Tavares None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 119 – A0281. doi:
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      Mariana Nadais Aidar, Camila Matsuura Endo, Patrick Israel Fligelman Kanas, Lisângela Morimoto, Diovani Costa Madeira, Yasmin Tournier Boppre, Andrea Cotait Kara-José, Henrique Ballalai Ferraz, Roberta Arb Saba, Eric Pinheiro Andrade, Ivan Maynart Tavares; Interocular retinal nerve fiber layer thickness in Parkinson disease. Invest. Ophthalmol. Vis. Sci. 2022;63(7):119 – A0281.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : According to Sheir et al. and Satue et al., some OCT studies demonstrated asymmetrical involvement of the retina in Parkinson's disease (PD).
Satue et al., correlated both macular and RNFL thickness with PD severity using the Hoehn and Yahr scale.
This study aims to compare the thickness of the RNFL between the eyes of patients with PD.

Methods : A prospective cross-sectional observational study was conducted to evaluate the RNFL thickness, global and sectorial (superior, inferior, nasal and temporal quadrants), of both eyes in patients with PD. The study protocol was approved by the Committee of Ethics in Research.
A group of 28 patients with PD, consisting of 16 men (57.14%) and 12 women (42.86%), was evaluated.
The recruitment of patients was carried out at the movement disorders clinic, according to the clinical criteria and Hoehn and Yahr scale.
All patients underwent a comprehensive ophthalmologic examination previously to the OCT exam.
The statistical analyses were performed using the paired t-test. A probability (p) value of ≤0.05 with a two-tailed rejection region was considered statistically significant.

Results : A group of 28 patients with PD, consisting of 16 men (57.14%) and 12 women (42.86%), was evaluated. The mean age of the patients was 63.8±12.1 (median 63; range, 42-88) years - table 1.
The mean RNFL thickness in the right eye of those patients, was 121±23 (median 123) µm at the superior quadrant, 125±25 (median 125) µm at the inferior quadrant, 71±15 (median 69) µm at the temporal quadrant, and 78±21 (median 80) µm at the nasal quadrant; and in the left eye, there was a mean RNFL thickness of 123±21 (median 121) µm at the superior quadrant, 127±23 (median 128) µm at the inferior quadrant, 70±13 (median 71) µm at the temporal quadrant, and 77±13 (median 79) µm at nasal quadrant - table 2.
No statistically significant differences (p>0.90) were found when comparing the RNFL thickness, in all quadrants, between right and left eyes.
Three patients in the present study had stage 1.5 on the Hoehn and Yahr scale, while 21 patients had stage 2 and four patients had stage 2.5, meaning that only patients in mild to moderate degrees were evaluated.

Conclusions : The present study demonstrated that in mild to moderate stages of the Hoehn and Yahr scale there are no asymmetry in RNFL thickness between eyes of patients with PD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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