Purchase this article with an account.
Veronica Romero Morales, Elodie Bousquet, swathi somisetty, Ahmad Santina, Neda Abraham, Anthony Lu, Meira Fogel Levin, Timothy J. Peiris, Brian Lee, David Sarraf; Correlation of Paravascular Inner Retinal Defects with Posterior Vitreous Detachment Using En Face OCT. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1009 – F0256.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Paravascular inner retinal defects (PIRD) are a well-known association of myopia and epiretinal membranes (ERM). We aimed to determine if PIRD can also be correlated with the presence and stage of posterior vitreous detachment (PVD) using en face optical coherence tomography (OCT).
This was a retrospective cross-sectional, observational, single center study. 9x9 mm and 12x12 mm en face optical coherence tomography (OCT) images (Solix Full Range OCT, Optovue) were reviewed from an OCT angiography database from a single medical retina office (DS) at the Stein Eye Institute at UCLA. PIRD were confirmed with analysis of both the en face OCT and the corresponding B scan. PVD was graded according to the corresponding OCT B scan. PIRD were classified as paravascular retinal cysts (without communication to the vitreous cavity) versus paravascular lamellar holes (with communication to the vitreous cavity) and according to the number of PIRD a) one PIRD versus b) 2 or more PIRD.
En face OCT datasets from 1137 patients were reviewed. A total of 272 eyes from 176 patients (15.49%) showed evidence of at least one PIRD in one eye. The mean age of this cohort was 70.5 ±13.5 years and 100 (57%) were female. In eyes with PIRD, grade 0 PVD was noted in 25 eyes (13%), grade 1 PVD in 32 eyes (16%), grade 2 PVD in 15 eyes (8%), grade 3 PVD in 22 eyes (11%), and grade 4 PVD in 178 eyes (71%).Of the 272 eyes, 153 (56.25%) displayed paravascular retinal cysts and 119 (43.75%) displayed paravascular lamellar holes. Paravascular lamellar holes were observed in 3 eyes (12%) without PVD, 34 eyes (49.3%) with partial PVD (stage 1 to 3), and 82 eyes (46.1%) with complete PVD (p=0.003). Two or more PIRD were found in 9 eyes (36%) without PVD and in 171 eyes (69%) with partial or complete PVD (stage 1 to 4) (p=0.001).
PIRD are a well-known complication of myopia and ERM. This study correlated the presence and grade of PVD with the development of PIRD. PIRD likely develop as a result of chronic vitreoretinal traction, especially in areas of increased traction as occurs along the major retinal vessels. En face OCT is an effective tool to detect PIRD.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.
This PDF is available to Subscribers Only