June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Sustained release of EOBO rewetting agent from a new silicone hydrogel contact lens material
Author Affiliations & Notes
  • Ying Zheng
    Alcon Laboratories Inc, Johns Creek, Georgia, United States
  • Jinbo Dou
    Alcon Laboratories Inc, Johns Creek, Georgia, United States
  • Young Hyun Kim
    Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, California, United States
    Herbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States
  • Clayton J Radke
    Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, California, United States
    Herbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States
  • James Wu
    Alcon Laboratories Inc, Johns Creek, Georgia, United States
  • Footnotes
    Commercial Relationships   Ying Zheng None; Jinbo Dou None; Young Hyun Kim None; Clayton Radke None; James Wu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 523 – A0221. doi:
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    • Get Citation

      Ying Zheng, Jinbo Dou, Young Hyun Kim, Clayton J Radke, James Wu; Sustained release of EOBO rewetting agent from a new silicone hydrogel contact lens material. Invest. Ophthalmol. Vis. Sci. 2022;63(7):523 – A0221.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A newly designed surface wettable silicone hydrogel (SiHy) contact lens material was studied based on sustained release of amphiphilic rewetting agent, EOBO [poly(oxyethylene)-co-poly(oxybutylene)]. The purpose of this study was to evaluate the uptake and release profiles of EOBO from the SiHy lens material.

Methods : The EOBO uptake profile into the lens matrix was evaluated with a fluorescence microscope using a fluorescent EOBO (Figure 1). EOBO release from the lens to a fixed volume of phosphate buffered saline (PBS) was measured with high-performance liquid chromatography (HPLC) at various times (Figure 2). Fick’s second law and EOBO concentration measurements at equilibrium were used to obtain the diffusion coefficient and the partition coefficient of EOBO.

Results : Diffusion coefficient of EOBO measured was ~10-11 cm2/s, which is about three to four magnitudes less than that of polymers with similar hydrodynamic radius. In addition, the lens partition coefficient of over 100 for EOBO indicated strong favorable interactions between EOBO and the hydrogel lens matrix. Lower molecular weight or more hydrophilic portion of EOBO preferentially released, whereas higher molecular weight or less hydrophilic EOBO practically retained within the bulk material. The unique interaction between the lens material and the rewetting agent contributed to the prolonged release of EOBO from the SiHy material. Results showed that EOBO released continuously from the bulk material for more than 7 days (Figure 2).

Conclusions : An in-vitro study and theoretical modeling were conducted on a new surface wettable SiHy contact lens material with a sustained release rewetting agent EOBO to demonstrate the feasibility of an enhanced re-wettable contact lens material. The unique interaction between the lens material and the rewetting agent contributed to the sustained release of EOBO from the SiHy lens material for more than 7 days.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1. Fluorescence micrographs of EO45BO10-NBD absorbed into a silicone hydrogel contact lens in the “infinite” bath at various times. The contact lens was cut in cross-section, and the yellow line is the cross-scan line from one side to the other side of the contact lens.

Figure 1. Fluorescence micrographs of EO45BO10-NBD absorbed into a silicone hydrogel contact lens in the “infinite” bath at various times. The contact lens was cut in cross-section, and the yellow line is the cross-scan line from one side to the other side of the contact lens.

 

Figure 2. Release profile of EOBO from an EOBO saturated lens to a fixed PBS volume. Square symbols represent the measured concentration in PBS by HPLC. The red line is fit from diffusion theory.

Figure 2. Release profile of EOBO from an EOBO saturated lens to a fixed PBS volume. Square symbols represent the measured concentration in PBS by HPLC. The red line is fit from diffusion theory.

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