June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Physiology-enhanced data analysis of the Thessaloniki Eye Study: relationship between intraocular pressure and venous resistance
Author Affiliations & Notes
  • Rajat Rai
    Electrical Engineering and Computer Science, University of Missouri System, Columbia, Missouri, United States
  • Giovanna Guidoboni
    Electrical Engineering and Computer Science, University of Missouri System, Columbia, Missouri, United States
  • James Keller
    Electrical Engineering and Computer Science, University of Missouri System, Columbia, Missouri, United States
  • Daphne Zou
    Electrical Engineering and Computer Science, University of Missouri System, Columbia, Missouri, United States
  • Christopher Wikle
    Statistics, University of Missouri System, Columbia, Missouri, United States
  • Erin L. Robinson
    School of Social Work, University of Missouri System, Columbia, Missouri, United States
  • Maggie Lin
    Mathematics, University of Missouri System, Columbia, Missouri, United States
  • Roberto Nunez
    Electrical Engineering and Computer Science, University of Missouri System, Columbia, Missouri, United States
  • Brent A Siesky
    Opthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alice Verticchio
    Opthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Barbara M Wirostko
    Opthalmology, University of Utah Health, Salt Lake City, Utah, United States
  • Dimitrios Giannoulis
    Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Vassilis Kilintzis
    Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Fotis Topouzis
    Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Alon Harris
    Opthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Rajat Rai None; Giovanna Guidoboni Foresite HealthCare LLC, Code C (Consultant/Contractor), Gspace LLC, Code I (Personal Financial Interest); James Keller None; Daphne Zou None; Christopher Wikle None; Erin Robinson None; Maggie Lin None; Roberto Nunez None; Brent Siesky None; Alice Verticchio None; Barbara Wirostko None; Dimitrios Giannoulis None; Vassilis Kilintzis None; Fotis Topouzis None; Alon Harris AdOM, Qlaris, Luseed, Cipla, Code C (Consultant/Contractor), :AdOM, Luseed, Oxymap, Qlaris, Phileas Pharma, SlitLed, QuLent, Code I (Personal Financial Interest), AdOM, Qlaris, Phileas Pharma, Code S (non-remunerative)
  • Footnotes
    Support  This work was supported in part by a Challenge Grant award from Research to Prevent Blindness, NY, and by the NSF grants DMS 1853222/2021192 and DMS 2108711/2108665.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4033 – A0418. doi:
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      Rajat Rai, Giovanna Guidoboni, James Keller, Daphne Zou, Christopher Wikle, Erin L. Robinson, Maggie Lin, Roberto Nunez, Brent A Siesky, Alice Verticchio, Barbara M Wirostko, Dimitrios Giannoulis, Vassilis Kilintzis, Fotis Topouzis, Alon Harris; Physiology-enhanced data analysis of the Thessaloniki Eye Study: relationship between intraocular pressure and venous resistance. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4033 – A0418.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose :
Physiology-enhanced data analytics provide a platform to quantify the contributions of various risk factors to primary open angle glaucoma (POAG) pathogenesis, a requirement for personalized disease management. Here, physiology-enhanced data analytics is used to estimate intraocular pressure (IOP) and its relationship to vascular resistance in the retinal venules and central retinal vein (CRV) in participants of the Thessaloniki Eye Study (TES).

Methods :
TES involved 3136 eyes including 98 POAG eyes and 423 eyes suspected of POAG. Structural and vascular assessments were conducted via Heidelberg Retinal Tomography (HRT) and Flowmetry (HRF). IOP and systolic and diastolic blood pressures (SBP, DBP) were used as individualized input data for a validated mathematical model (Guidoboni et al 2014), providing hemodynamic outputs based on fundamental mechanisms of vascular physiology. The enhanced dataset is made by the combination of collected and simulated data.

Results :
OAG eyes had higher IOP and lower DBP compared to healthy eyes and POAG suspects. Diastolic CRV resistance was significantly higher (5-fold) in POAG eyes compared to healthy eyes. In glaucoma suspects compared to healthy, median CRV resistance was similar, while the 75th percentile was much higher (Table 1). The differences in the venous resistances are also accompanied by significant differences in structural and vascular biomarkers (Table 1).

Conclusions :
Hemodynamic alterations in the venous circulation may influence the relationship between IOP and glaucoma and alter risk. In addition, increased vascular resistances of the retinal veins are indicative of higher susceptibility to vessel collapse in patients with POAG.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Table 1: Medians with the 25th and the 75th percentile values of different variables for non-glaucoma, POAG and POAG suspect eyes

Table 1: Medians with the 25th and the 75th percentile values of different variables for non-glaucoma, POAG and POAG suspect eyes

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