June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Relationships between the Optic Nerve Head in Optical Coherence Tomography and Optic Nerve Volume in Magnetic Resonance Imaging in Glaucoma
Author Affiliations & Notes
  • Zain Khera
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Ronald Zambrano
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Eitan Shemuelian
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Lei Zheng
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Vivek Trivedi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Hiroshi Ishikawa
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Ophthalmology, Oregon Health & Science University Casey Eye Institute, Portland, Oregon, United States
  • Joel S Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Departments of Biomedical Engineering and Electrical and Computer Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Kevin C. Chan
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Radiology, NYU Langone Health, New York, New York, United States
  • Footnotes
    Commercial Relationships   Zain Khera None; Ronald Zambrano None; Eitan Shemuelian None; Lei Zheng None; Vivek Trivedi None; Hiroshi Ishikawa None; Joel Schuman Zeiss, Inc, Code P (Patent); Kevin Chan None
  • Footnotes
    Support  This work was supported in part by the National Institutes of Health R01-EY013178 and R01-EY028125, (Bethesda, Maryland); and an unrestricted grant from Research to Prevent Blindness to NYU Langone Health Department of Ophthalmology (New York, New York).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3362 – F0171. doi:
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    • Get Citation

      Zain Khera, Ronald Zambrano, Eitan Shemuelian, Lei Zheng, Vivek Trivedi, Hiroshi Ishikawa, Joel S Schuman, Kevin C. Chan; Relationships between the Optic Nerve Head in Optical Coherence Tomography and Optic Nerve Volume in Magnetic Resonance Imaging in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3362 – F0171.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Deep learning of optical coherence tomography (OCT) may help discriminate glaucomatous eyes from healthy controls. However, the underlying decision making processes remain unclear. Recently, through computing class activation maps, our feature agnostic artificial intelligence of OCT images using a 3D convolutional neural network identified the optic nerve head (ONH) and its surrounding regions as structures significantly associated with glaucoma classification (PMID: 31260494). To pursue their contributions further, here we analyzed the optic nerve morphology from OCT and magnetic resonance imaging (MRI) in a subset of glaucoma and healthy subjects.

Methods : Nine early glaucoma, 12 advanced glaucoma, and 4 healthy control subjects underwent spectral-domain OCT at 30x30x2 µm3 and 3-Tesla anatomical MRI at 1x1x1mm3. Maximum intensity projection was applied to en-face OCT scans at the ONH (Fig. 1). The areas of the ONH [inner regions of interest, (ROI)] and surrounding regions (outer ROIs) visible in OCT were measured using global thresholding in ImageJ. One-way ANOVAs with post-hoc Tukey’s tests were performed on the inner and outer ROIs between the 3 groups. Also, a Pearson correlation analysis was performed between the ROI areas in OCT and optic nerve volume extracted from MRI between the eye and optic chiasm.

Results : For OCT of the ONH, significant group effect was observed for the areas in the inner ROIs (ANOVA: F= 7.823, p=0.00133). Post-hoc analyses revealed a significant difference between healthy controls and advanced glaucoma (p=0.0082) and between early and advanced glaucoma (p=0.0057) but no significance between healthy controls and early glaucoma (p=0.80) (Fig. 2A). No significant group effect was observed in the outer ROIs (ANOVA: F=0.004, p=0.996) (Fig. 2B). There was a negative correlation between the inner ROI area in OCT and optic nerve volume in MRI (R=-0.47, p=0.0011) (Fig. 2C).

Conclusions : The ONH tissues visible on OCT appeared to contribute more than their surrounding regions to distinguishing between glaucomatous eyes and healthy eyes. The negative correlation between ONH area in OCT and optic nerve volume in MRI suggested the need to further understand the interactions between ONH and deeper brain structures in glaucoma.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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