June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Bacillary layer detachment in Vogt-Koyanagi-Harada disease: a biomarker with prognostic value
Author Affiliations & Notes
  • Ruy Felippe Missaka
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Mauro Goldbaum
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Cleide Guimarães Machado
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Fernanda Maria Silveira Souto
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Priscilla Figueiredo Nóbrega
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Marcelo Mendes Lavezzo
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Viviane Mayumi Sakata
    Ophthalmology, Universidade Federal do Parana, Curitiba, PR, Brazil
  • Maria Kiyoko Oyamada
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Carlos Eduardo Hirata
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Joyce H Yamamoto
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships   Ruy Felippe Missaka None; Mauro Goldbaum None; Cleide Machado None; Fernanda Maria Silveira Souto None; Priscilla Nóbrega None; Marcelo Lavezzo None; Viviane Sakata None; Maria Oyamada None; Carlos Hirata None; Joyce Yamamoto None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3361 – F0170. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ruy Felippe Missaka, Mauro Goldbaum, Cleide Guimarães Machado, Fernanda Maria Silveira Souto, Priscilla Figueiredo Nóbrega, Marcelo Mendes Lavezzo, Viviane Mayumi Sakata, Maria Kiyoko Oyamada, Carlos Eduardo Hirata, Joyce H Yamamoto; Bacillary layer detachment in Vogt-Koyanagi-Harada disease: a biomarker with prognostic value. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3361 – F0170.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To report the frequency of bacillary layer detachment (BLD) and its associations with clinical and visual function outcomes of patients with Vogt-Koyanagi-Harada disease (VKHD).

Methods : Retrospective analysis of 33 patients with VKHD followed for a minimum one year since the acute disease onset with systematic clinical, multimodal imaging and visual function evaluations. All patients were treated with high-dose systemic corticosteroid; 23 patients had additional oral azathioprine. Three independent retina specialists read the images obtained in the spectral domain-OCT (Heidelberg Engineering, Heidelberg, Germany) at baseline (M0) and at the 1st, 3rd, 6th, 9th and 12th months. Frequency of BLD was analysed for its association with other OCT findings, clinical and visual outcomes. Generalized estimating equations (GEE) of binomial distribution and logit link function with interchangeable correlation between eyes and moments were carried out. This study was approved by Institutional Ethics Committee and followed Helsinki declaration.

Results : Included patients (29 female/ 4 male) had a median age of 33 years (15 to 67 years) with a median disease duration of 67 months (27 to 121 months). The median initial visual acuity (VA) was 1.8 logMAR (0 to 2.3 logMAR), 0.2 logMAR (0 to 2 logMAR) at M1 and 0 logMAR (0 to 0.7 logMAR) at M12. Sunset glow fundus (SGF) was seen in 42 eyes (63%) and subnormal full-field electroretinogram (ffERG) was seen in 76% of eyes (47/62) in M12. BLD was present in 87.5% (49/56) of eyes at M0 and in 3% (2/66) at M6 and M9. BLD resolution time was longer compared to serous retinal detachment (SRD) with medians of 1 month (0 to 12 months) and 0 month (0 to 9 months), respectively (Figure). Significant associations were observed between BLD in M1 with worse VA in M0 (median 1.8 vs 1 logMAR; p=0.016); worse VA (median 0.25 vs 0.05 logMAR; p=0.014), worse fluorescein angiography scores (9 vs 5; p=0.002) and indocyanine green angiography scores (15 vs 10.5p= 0.007) in M1; severe fundus (p=0.008), SGF (p=0.006), fibrosis (p=0.005), chorioretinal atrophy (p=0.008), and subnormal ffERG (p=0.045) in M12, as well as longer elipsoid zone resolution time (median 12 vs 3 months; p=0.006 ) (Table).

Conclusions : Our data pointed out the presence of BLD in M1 as a potential biomarker of a worse prognosis in VKHD, as evidenced by changes in fundus and visual function at 12 months.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×