June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Age-dependence of the objective optical and mechanical accommodative response measured using a combined dynamic autorefractor and OCT system
Author Affiliations & Notes
  • Bianca Maceo Heilman
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Heather Durkee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Leana Rohman
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Arthur Ho
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Bianca Maceo Heilman None; Heather Durkee None; Marco Ruggeri US patent 8,425,037, Code P (Patent); Leana Rohman None; Arthur Ho None; Jean-Marie Parel US patent 8,425,037, Code P (Patent); Fabrice Manns US patent 8,425,037, Code P (Patent)
  • Footnotes
    Support  NEI Grants: 2R01EY14225, P30EY14801 (Center Core Grant); the Florida Lions Eye Bank and the Beauty of Sight Foundation; an unrestricted grant from Research to Prevent Blindness; Australian Federal Government CRC Program (Vision CRC); the Henri and Flore Lesieur Foundation (JMP); donations from Drs. HW, Flynn, KR Olsen and ME Hildebrandt, and Raksha Urs and Aaron Furtado.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3068 – F0540. doi:
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      Bianca Maceo Heilman, Heather Durkee, Marco Ruggeri, Leana Rohman, Arthur Ho, Jean-Marie Parel, Fabrice Manns; Age-dependence of the objective optical and mechanical accommodative response measured using a combined dynamic autorefractor and OCT system. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3068 – F0540.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To develop approaches to restore accommodation, research has focused on studying the age-related changes leading to presbyopia. Prior studies have quantified changes in lens shape in response to static accommodative demands, but there is limited data on the relation between lens shape and objective accommodation, and the dynamics of lens shape changes. The goal of this study is to quantify the age-dependence of the optical and biometric accommodative response using a custom-built combined autorefractor and OCT system.

Methods : Accommodative responses of 12 subjects aged 20 to 66 years (mean spherical equivalent refraction −1.67 ± 2.30 D, range -6.25 to 1.75 D) were measured using a device that combined a fixation target providing a controlled ramp accommodation stimulus, wavefront-based autorefractor, and an extended-depth OCT system that acquires images of the anterior segment and lens. Subjects were presented with a 12 D ramp stimulus at a speed of 0.5 D/s. Wavefront measurements and cross-sectional OCT images were acquired sequentially in real-time during the ramp at 33 Hz and 4.7 frames/s, respectively. Three runs were performed on each subject. Lens thickness was quantified from the OCT images using a semi-automatic segmentation software. The following parameters were quantified versus age: maximal accommodation, lens thickness change, accommodation response vs stimulus, lens thickness per D stimulus, and the relation between lens thickness change and optical accommodative response.

Results : Refraction and lens thickness varied linearly with stimulus. The optical response to a given stimulus decreased with age at a rate of 0.023 D/D/year. (Figure 1C) There was no statistically significant age-dependence of the change in lens thickness per Diopter of accommodative response in pre-presbyopic eyes (Age <50 years, average: 0.032 mm/D). (Figure 1D)

Conclusions : The decrease in accommodative gain (response/stimulus) combined with constancy of the lens thickness per Diopter response lends further support to the theory that attributes presbyopia to age-related changes in the ability of the lens to change shape.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1: AR-OCT OCT data (12 D ramp stimulus, 0.5 D/s). A) Maximal accommodation vs age, B) lens thickness change vs age, C) accommodation response per D stimulus vs age, and D) thickness change per D of accommodation vs age.

Figure 1: AR-OCT OCT data (12 D ramp stimulus, 0.5 D/s). A) Maximal accommodation vs age, B) lens thickness change vs age, C) accommodation response per D stimulus vs age, and D) thickness change per D of accommodation vs age.

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