June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Simultaneous Assessment of the Whole Eye Biomechanics Using High Frequency Ultrasonic Elastography
Runze Li; Xuejun Qian; Chen Gong; Ying Liu; Junhang Zhang; Benjamin Xu; Mark S Humayun; Qifa Zhou
Author Affiliations & Notes
  • Runze Li
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Xuejun Qian
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Chen Gong
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
  • Ying Liu
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Junhang Zhang
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
  • Benjamin Xu
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Mark S Humayun
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Qifa Zhou
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Runze Li None; Xuejun Qian None; Chen Gong None; Ying Liu None; Junhang Zhang None; Benjamin Xu None; Mark Humayun None; Qifa Zhou None
  • Footnotes
    Support  NIH P30EY029220, R01EY032229, R01EY028662,
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2732 – A0096. doi:
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      Runze Li, Xuejun Qian, Chen Gong, Ying Liu, Junhang Zhang, Benjamin Xu, Mark S Humayun, Qifa Zhou; Simultaneous Assessment of the Whole Eye Biomechanics Using High Frequency Ultrasonic Elastography. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2732 – A0096.

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Abstract

Purpose : Conventional elastography usually targets and assesses the biomechanical properties of specific ocular structures, for example, the cornea. However, there are some diseases that are broadly impacted by different structures across the entire eye. Glaucomatous optic neuropathy, for example, is associated with increased stiffness in the cornea, sclera, and iris. Therefore, there is a need to develop a tool that can concurrently quantify the biomechanical properties of multiple ocular structures. In this study, we aim to develop a high frequency array based ultrasonic elastography (HFUE) to meet this requirement.

Methods : A 18 MHz linear array was used for imaging and elastic wave acquisition. The rabbit was first anesthetized and positioned, and a shaker tip was brought into contact with the corneal limbus to initiate the elastic wave. An infusion line and intraocular pressure (IOP) sensor were inserted into the posterior segment of the eye through trocars. The height of infusion line was modulated to elevate the IOP. To capture the elastic wave propagation with fine image quality, the acquisition speed was set to 10 KHz. Pulse-width of shaker was set to 1 ms to induce vibrations while maintaining a broad bandwidth of the elastic wave. Raw data was saved for further analysis. Group velocity was calculated to reconstruct the Young’s modulus.

Results : Figure 1 shows the elastic wave mapping of the eye and the corresponding B-mode imaging during different levels of IOP. Figure 2 shows the biomechanical response of cornea, lens, iris, parapapillary sclera (PPS), and optic nerve head (ONH) to the different IOPs levels. The Young’s modulus of cornea and iris has a linear relation with IOP, PPS and ONH has an second polynomial relation with IOP, while lens is not affected by IOP.

Conclusions : Our elastopgrahy system can concurrently assess the biomechanical properties of multiple ocular structures and detecting the changes in biomechanical properties associated with changes in IOP.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1. Elastic wave distribution mapping and the corresponding B-mode images.
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Figure 1. Elastic wave distribution mapping and the corresponding B-mode images.

Figure 1. Elastic wave distribution mapping and the corresponding B-mode images.

Figure 1. Elastic wave distribution mapping and the corresponding B-mode images.
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Figure 2. The Young's modulus of conrea, lens, iris, PPS and ONH to the elevated IOPs.
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Figure 2. The Young's modulus of conrea, lens, iris, PPS and ONH to the elevated IOPs.

Figure 2. The Young's modulus of conrea, lens, iris, PPS and ONH to the elevated IOPs.

Figure 2. The Young's modulus of conrea, lens, iris, PPS and ONH to the elevated IOPs.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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