June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Optic Nerve Head, Choroidal Thickness and Individual Macular Layers Measurements with Optical Coherence Tomography in Normal and Glaucoma Eyes with Distinct Peripapillary Atrophy Areas
Author Affiliations & Notes
  • Fabio Lavinsky
    School of Medicine, Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, Brazil
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
  • Valentina Mostardeiro Lubisco
    School of Medicine, Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, Brazil
  • Henrique Bohn
    School of Medicine, Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, Brazil
  • Alessandra Tofani de Barros
    School of Medicine, Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, Brazil
  • Fernanda Mari Fagundes Fujihara
    Ophthalmology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
  • Luciano Porto Bellini
    School of Medicine, Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, Brazil
  • Rodrigo Leivas Lindenmeyer
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
  • Helena Messinger Pakter
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
  • Jaco Lavinsky
    Ophthalmology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
  • Egidio Picetti
    Hospital Conceicao, Porto Alegre, Rio Grande do Sul, Brazil
  • Daniel Lavinsky
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
  • Paulo Augusto de Arruda Mello
    Ophthalmology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
  • Footnotes
    Commercial Relationships   Fabio Lavinsky None; Valentina Lubisco None; Henrique Bohn None; Alessandra Barros None; Fernanda Fujihara None; Luciano Bellini None; Rodrigo Lindenmeyer None; Helena Pakter None; Jaco Lavinsky None; Egidio Picetti None; Daniel Lavinsky None; Paulo Augusto Mello None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2424 – A0358. doi:
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      Fabio Lavinsky, Valentina Mostardeiro Lubisco, Henrique Bohn, Alessandra Tofani de Barros, Fernanda Mari Fagundes Fujihara, Luciano Porto Bellini, Rodrigo Leivas Lindenmeyer, Helena Messinger Pakter, Jaco Lavinsky, Egidio Picetti, Daniel Lavinsky, Paulo Augusto de Arruda Mello; Optic Nerve Head, Choroidal Thickness and Individual Macular Layers Measurements with Optical Coherence Tomography in Normal and Glaucoma Eyes with Distinct Peripapillary Atrophy Areas. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2424 – A0358.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study is to evaluate the differences in optic nerve head (ONH), choroidal thickness and individual macular layers measurements in normal and glaucoma eyes in groups divided by the area of their peripapillary atrophy (PPA).

Methods : Subjects with glaucoma presenting typical ONH findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. Patients underwent 24-2 perimetry (SITA standard;Humphrey Field Analyzer; Zeiss) and Spectral Domain Optical Coherence Tomography (SD-OCT) (Spectralis;Heidelberg Engineering). Manual measurements of the temporal and superior and inferior-temporal PPA area observing the infrared image and the B-scans were manually performed by a trained examiner. Eyes were divided in four groups based on the PPA area. SD-OCT parameters analyzed were average circumpapillary retinal nerve fiber layer (cRNFL), average circumpapillary choroidal thickness (cChoroid), the hypotenuse of the vertical optic nerve head cupping (HVOC) and the individual macular layers obtained automatically from the device. For calculating HVOC we used the length and depth of the optic nerve cupping as the sides of a right triangle. The mean deviation (MD) of the VF was evaluated. Statistical analysis was performed using generalized estimated equations.

Results : 89 eyes (57 subjects) qualified for the study. The mean age was 65.72±12.47 years. The number of eyes was 81 in the glaucoma and 8 in the control group. Four groups were divided by the quartiles of the PPA area: 1: ≤ 0.44 mm2 (n=24); 2: 0.44-0.69 mm2 (n=21); 3: 0.69-0.92 mm2 (n=22) and 4: ≥ 0.92 mm2 (n=22). The control eyes distribution was: 6 eyes in group 1, 2 in group 2 and none in groups 3 and 4. cRNFL, HVOC and inner macular layers demonstrated overall significant differences between groups (table 1). VF MD, additional macular layers and cChoroid differences weren’t significant, except for the outer plexiform layer (OPL) in the outer circle of the grid (table 2).

Conclusions : Eyes with distinct PPA areas demonstrated differences in ONH and macular parameters related to glaucoma. Longitudinal studies evaluating PPA area and the associated change in other structural and functional parameters may provide additional information about the clinical course of glaucomatous eyes with PPA.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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