Abstract
Purpose :
We reported previously that the retinal blood flow parameters were associated with systemic atherosclerosis in patients with acute coronary syndrome (ACS) (Ebuchi, Nagaoka, 2022, Sci Rep). However, the relation between atherosclerosis and choroidal blood flow parameters remains unclear. This study investigated the relationship between choroidal blood flow parameters using laser speckle flowgraphy (LSFG) and the systemic risk factors for atherosclerosis including brachial-ankle pulse-wave velocity (baPWV) and intima-media thickness (IMT) in patients with ACS.
Methods :
We evaluated 44 patients with ACS between April 2019 and September 2020. Using LSFG, we measured the choroidal mean blur rate (MBR) as an index of choroidal blood flow from both regions nasally (MBR-N) from the disc without large retinal vessels and compared the results with systemic risk factors including the baPWV and IMT.
Results :
Significant positive correlations were observed between the baPWV and the maximal MBR-N (r = 0.466, P = 0.001) and the IMT and the minimal MBR-N (r = -0.354, P = 0.02).
Conclusions :
The choroidal MBR in the nasal region was associated with systemic atherosclerosis in patients with ACS, suggesting that the measurement may be a useful, non-invasive biomarker for cardiovascular diseases.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.