June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The influence of drusenoid pigment epithelial detachment characteristics on the progression to late-stage age-related macular degeneration
Author Affiliations & Notes
  • Marlene Hollaus
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Johannes Iby
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Jonas Brugger
    Center for Medical Data Science, Medizinische Universitat Wien, Wien, Wien, Austria
  • Oliver Leingang
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Gregor Sebastian Reiter
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Stefan Sacu
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Marlene Hollaus None; Johannes Iby None; Jonas Brugger None; Oliver Leingang None; Gregor Reiter RetInSight, Code F (Financial Support); Ursula Schmidt-Erfurth Apellis, Code C (Consultant/Contractor), Genentech, Kodiak, Novartis, Apellis, RetInSight, Code F (Financial Support), RetInSight, Code P (Patent); Stefan Sacu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 297. doi:
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      Marlene Hollaus, Johannes Iby, Jonas Brugger, Oliver Leingang, Gregor Sebastian Reiter, Ursula Schmidt-Erfurth, Stefan Sacu; The influence of drusenoid pigment epithelial detachment characteristics on the progression to late-stage age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):297.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze the presence and morphologic characteristics of drusenoid pigment epithelial detachments (DPEDs) in spectral-domain optical coherence tomography (SD-OCT) in patients with early and intermediate age-related macular degeneration as well as the influence of these characteristics on disease progression.

Methods : In this prospective observational study, 89 eyes of 56 patients were included. Examinations consisted of best-corrected visual acuity (BCVA), SD-OCT and indocyanine green angiography. Evaluated parameters included drusen type, mean drusen height and -volume, the presence of DPED, DPED maximum height, -width, volume, topographic location in the Early Treatment Diabetic Retinopathic Study (ETDRS)-Grid and the development of macular neovascularization (MNV) or geographic atrophy (GA).

Results : In our study patients, DPED maximum height (162.34µm±75.70µm) was significantly associated with the development of GA and MNV (15 eyes /17% and 9 eyes/10%, respectively; p = 0.019). For each 100µm more maximum height, the odds of development of GA or MNV increase by 2.23 (95% CI=1.14 to 4.35). However, there was no significant difference in between the late stages (GA vs MNV, p=0.15). Furthermore, the presence of DPED (44 eyes, p=0.01), its volume (0.20mm3±0.20mm3, p=0.01), maximum width (1860.87µm±880.74µm, p=0.03) and maximum height (162.34µm±75.70µm, p <0.001) were significantly correlated with BCVA at the last follow-up (0.15 logMar±0.20 logMar; Snellen equivalent approximately 20/28): In patients with DPED, visual acuity is expected to be worse by 0.093 logMar [0.022; 0.164], with each 1/10mm3 higher volume by 0.030 logMar [0.008; 0.053], with each 1000µm more width by 0.037 logMar [0.004; 0.070] and with each 100µm more height by 0.071 logMar [0.035; 0.107]. DPEDs occur significantly less in the outer quadrants than in the central millimeter and inner quadrants of the ETDRS-Grid (all p-values < 0.001).

Conclusions : The maximum height of DPEDs seems to be a biomarker that is significantly associated with the development of late stage AMD. Furthermore, the presence of DPED, DPED volume, maximum width and maximum height were significantly correlated with visual loss. Topographically, DPEDs affect predominantly the center and inner quadrants of the ETDRS-Grid.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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