June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Anterior Chamber Depth and Angle and Associations in a Pediatric and Adult Population in Russia
Author Affiliations & Notes
  • Mukharram Bikbov
    Ufa Eye Research Institute, Ufa, Russian Federation
  • Gyulli Kazakbaeva
    Ufa Eye Institute, Ufa, Russian Federation
  • Songhomitra Panda-Jonas
    Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany
  • Ellina Iakupova
    Ufa Eye Institute, Ufa, Russian Federation
  • Jost B. Jonas
    Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Footnotes
    Commercial Relationships   Mukharram Bikbov None; Gyulli Kazakbaeva None; Songhomitra Panda-Jonas None; Ellina Iakupova None; Jost Jonas None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 133. doi:
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      Mukharram Bikbov, Gyulli Kazakbaeva, Songhomitra Panda-Jonas, Ellina Iakupova, Jost B. Jonas; Anterior Chamber Depth and Angle and Associations in a Pediatric and Adult Population in Russia. Invest. Ophthalmol. Vis. Sci. 2023;64(8):133.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the normative data of anterior chamber depth(ACD) and angle(ACA) and their associations in multiethnic cohort spanning three generations in Bashkortostan/Russia.

Methods : Using Scheimflug camera-based anterior chamber imaging, we measured ACD and ACA in population-based studies performed within same geographical region: Ural Eye and Medical Study(UEMS;age:40+ years,n=5899), Ural Children Eye Study(UCES;age:6-18 years,n=4933), and Ural Very Old Study(UVOS;age:85+ years,n=1526).

Results : The study included 4869(98.7%,UCES) children with available keratometric readings, 5426(92.0%,UEMS), and 268 individuals(16.3%,UVOS). In UEMS, larger ACD(mean:3.14±0.37mm) correlated(mva;r2=0.57) with younger age(beta:-0.08;P<0.001), taller body height(BH)(beta:0.03;P=0.003), longer axial length(AL)(beta:0.34;P<0.001), higher corneal volume(CV)(beta:0.06;P<0.001) and corneal refractive power(CRP)(beta:0.12;P<0.001), wider ACA (beta:0.50;P<0.001), thinner lens thickness (LT)(beta:-0.09;P<0.001). A wider ACA(mean:31.23±6.46°) correlated with(mva,r2=0.50) with younger age(beta:-0.09;P<0.001), taller BH(beta:0.03;P=0.02), longer AL(beta:0.11;P<0.001), deeper ACD(beta:0.59;P<0.001), lower CV(beta:-0.09;P<0.001), higher CRP(beta:0.13;P<0.001), thinner LT(beta:-0.07;P<0.001). In UCES, larger ACD(mean:3.70±0.27mm) was associated(r2=0.51), longer AL(beta:0.60;P<0.001), lower CRP(beta:0.32;P<0.001), wider ACA(beta:-0.11;P<0.001), thinner LT(beta:-0.10;P<0.001), younger age(beta:-0.11;P<0.001), taller BH(beta:0.07;P<0.001). Larger ACA(mean: 39.67±6.63°) correlated with(r2=0.23) with younger age(beta:-0.09;P<0.001), longer AL(beta:0.20;P<0.001), deeper ACD(beta:0.42;P<0.001), higher CRP(beta:0.13;P<0.001). In UVOS, higher ACD(mean:2.96±0.56mm) was associated with(r2=0.15) younger age(beta:-0.15;P=0.01), longer AL(beta:0.28;P=0.01), taller BH(beta:0.10;P=0.04). Larger ACA(mean:28.6 ± 7.5°) correlated(r2=0.06) with longer AL(beta:0.15;P=0.02) and taller BH(beta: 0.16;P=0.02).

Conclusions : In this population-based cohort of 3 generations from Russia, ACD decreased from children cohort(mean:3.70 ± 0.27 mm) to adult(mean:3.14 ± 0.37 mm) and finally to very old cohort(2.96 ± 0.56 mm). Determinants of a shallow ACD were systemic parameters of older age and lower BH, in addition to ocular biometric parameters of shorter AL, lower CV and CRP, wider ACA, and thinner LT.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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