June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Effects of exogenous retinoic acid on retinal and choroidal parameters in guinea pigs with form deprivation myopia using enhanced depth imaging optical coherence tomography
Author Affiliations & Notes
  • Yajun Wu
    Ophthalmology, Aier School of Ophthalmology, Central South University, Changsha, Hunan, China
    Ophthalmology, Shanghai Aier Eye Hospital, Shanghai, China
  • Wensheng Li
    Ophthalmology, Aier School of Ophthalmology, Central South University, Changsha, Hunan, China
    Ophthalmology, Shanghai Aier Eye Hospital, Shanghai, China
  • Footnotes
    Commercial Relationships   Yajun Wu None; Wensheng Li None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 845. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yajun Wu, Wensheng Li; Effects of exogenous retinoic acid on retinal and choroidal parameters in guinea pigs with form deprivation myopia using enhanced depth imaging optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2023;64(8):845.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Enhanced depth imaging optical coherence tomography (EDI-OCT) can be used to obtain retinal thickness (RT) and choroidal thickness (CT) in guinea pigs. The aim of this study was to investigate the effects of exogenous retinoic acid and citral on form deprivation myopia (FDM) in guinea pigs.

Methods : Methods: 80 2-week-old male SPF guinea pigs were randomly divided into 4 groups: Group 1 (blank control group), group 2 (FDM group), group 3 (FMD+ retinoic acid group) and group 4 (FDM+ citral group), with 20 in each group. The right eye of all FDM guinea pigs was subjected to form deprivation, and the left eye was not treated. Group 3 was given 24 mg/kg retinoic acid dissolved in 0.4 ml peanut oil. Group 4 was given 445mg/kg citral dissolved in 0.4 ml peanut oil. Groups 1 and 2 were given 0.4ml peanut oil. After 4 weeks, using EDI-OCT to obtain RT and CT at 1PD below the optic disc of all guinea pigs.

Results : The RT of the right eye of the 4 groups was compared, group 1 > group 4 > group 2 > group 3, there was no statistical significance between group 2 and group 3 (p > 0.05), and there was statistical significance between the other two groups (p < 0.001). Compared with the RT of the left eye, only the RT of group 1 VS group 4 and group 1 VS group 3 had statistical differences (p < 0.05); Compared with the RT of the left eye and the right eye among the 4 groups, the RT of the right eye in group 2 and group 3 was significantly less than that in the left eye (p < 0.05). The CT of the right eye in group 1 was greater than that in the other three groups (p < 0.0001), but there was no statistically significant difference among groups 4, 2, and 3 (p > 0.05). There was no significant difference in the CT between group 3 and group 4 (p > 0.05), but there was a significant difference in the CT between the other groups (p < 0.05). There were significant differences in the CT between group 2 and group 3 (p < 0.001). There was a statistical difference in the CT between the left and right eyes in group 4 (p < 0.05), and the CT of the right eye was significantly less than that of the left eye in the above three groups (p > 0.05).

Conclusions : Exogenous RA can induce the thinning of the RT and CT in FDM guinea pigs. Citral can inhibit retinal thinning, but may not inhibit choroid thinning.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×