June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Chart-based contrast sensitivity in luminance noise for patients with diabetes mellitus
Author Affiliations & Notes
  • Frederick T Collison
    Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
    The Chicago Lighthouse, Chicago, Illinois, United States
  • J. Jason McAnany
    Department of Ophthalmology and Visual Sciences, University of Illinois Chicago College of Medicine, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Frederick Collison None; J. Jason McAnany University of Illinois at Chicago College of Medicine, Patent application ID number 16768493, Code P (Patent)
  • Footnotes
    Support  R01EY026004 P30EY001792, unrestricted funds from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1472. doi:
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      Frederick T Collison, J. Jason McAnany; Chart-based contrast sensitivity in luminance noise for patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1472.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the effect of diabetes mellitus on contrast sensitivity (CS) in luminance noise using a novel booklet-based letter CS test.

Methods : Ten subjects with type 2 diabetes mellitus (DM, age range 44-65; mean 54.6 years) and twenty control subjects (controls, age range 44-64; mean 54.7 years) participated in the study. All subjects recently underwent a comprehensive eye exam and had no known visual deficits or significant media opacity. Diabetics had no diabetic retinopathy and no diabetic macular edema. Subjects were tested using the right eye and asked to identify letters that spanned a broad range of Weber contrast (0.1% to 56%) printed in a novel booklet-based test. The letters were presented against a uniform gray background (no-noise condition) and in the presence of static spatial luminance noise (noise condition), which consisted of light and dark checks. CS in no-noise, CS in the presence of noise, and estimated equivalent intrinsic visual noise (Neq) were compared using unpaired two-tailed t-tests.

Results : CS measured in the no-noise condition was significantly worse for the DM group (mean log CS=1.56) than the controls (mean log CS=1.68, P<0.01), with 5 of the 10 DM subjects having log CS below the range of the 20 controls. On the other hand, CS in the noise condition was similar between the DM group (mean log CS 0.85) and the control group (mean log CS 0.86, P=0.78). Intrinsic noise was significantly worse for the DM group (mean log Neq=–5.17) than for the controls (mean log Neq=–5.41, P=0.026).

Conclusions : Diabetics may have reduced CS even in the absence of clinically evident retinopathy. The results of this study suggest that intrinsic visual noise may be part of the explanation for this CS reduction, and that this intrinsic noise can be measured with a chart-based test.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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