Abstract
Purpose :
To assess the response of chronic ocular pain patients to multiple interdisciplinary interventions and determine the baseline variables that are associated with treatment response.
Methods :
This was a retrospective study performed on patients referred to the Ocular Pain Service at the Cole Eye Institute from June 2020 to January 2022. Questionnaires routinely used by the multidisciplinary services were collected to document treatment response to interventions targeting increased tear production and decreased ocular inflammation, autologous serum tears, systemic therapies, and non-pharmacologic interventions. A retrospective chart review was performed to collect baseline demographic variables. Univariable analysis was performed to identify associations between baseline variables and the treatment outcome, followed by LASSO regression to assess the predictive ability of clinical features to predict outcomes. Statistical analyses were performed using R (version 3.5.1).
Results :
Analysis was performed on 133 patients (72.93% Female, 27.07% Male; Mean age of 52.37 years). Pain severity and usage of systemic medications were associated with treatment response to non-pharmacologic interventions (FDR P<0.2). Area under the receiver operating characteristic curve (AUC) of the predictive models for response to serum tears, systemic therapies and non-pharmacologic interventions were 0.51, 0.62 and 0.83, respectively. AUC values of the predictive models for response to interventions targeting increased tear production and decreased ocular inflammation were 0.68 and 0.64, respectively.
Conclusions :
The results of this study support a data-driven prediction of treatment response in chronic ocular pain to multiple interdisciplinary interventions, particularly for non-pharmacologic interventions.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.