June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Psychometric validity of the National Eye Institute Visual Function Questionnaire in patients with the m.11778G>A mutation causing Leber hereditary optic neuropathy
Author Affiliations & Notes
  • Benson Chen
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
  • John Britton
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
  • Patrick Yu-Wai-Man
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
  • Mike Horton
    Psychometric Laboratory for Health Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
  • Footnotes
    Commercial Relationships   Benson Chen None; John Britton None; Patrick Yu-Wai-Man None; Mike Horton None
  • Footnotes
    Support  BC is supported by the Cambridge-Rutherford Memorial Scholarship, awarded by the Royal Society Te Apārangi – Rutherford Foundation and the Cambridge Commonwealth, European & International Trust; and the Bushell Travelling Fellowship in Medicine or the Allied Sciences, awarded by the Royal Australasian College of Physicians (RACP) Foundation
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1952. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Benson Chen, John Britton, Patrick Yu-Wai-Man, Mike Horton; Psychometric validity of the National Eye Institute Visual Function Questionnaire in patients with the m.11778G>A mutation causing Leber hereditary optic neuropathy. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1952.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The National Eye Institute Visual Function Questionnaire (VFQ-25) is a 26-item (25 vision-related and 1 general health) patient-reported outcome measure, widely used to assess vision-related quality of life in a range of ocular conditions, including recent clinical trials for Leber hereditary optic neuropathy (LHON). The purpose of this study was to determine the psychometric validity of the VFQ-25 for use by patients with LHON.

Methods : Rasch analysis was conducted in two stages using data for 97 individuals (79.4% men; median age 28.9 years [interquartile range: 21.7 – 41.2]) in the subacute or dynamic stage of symptomatic LHON due to the m.11778G>A mutation, with vision loss in at least one eye. In stage 1, scale unidimensionality, scale-to-sample targeting, response category threshold ordering, item fit statistics, local dependency, and reliability were assessed. In stage 2, a post-hoc revision of the VFQ-25 scoring structure was created and psychometrically re-evaluated.

Results : In stage 1, issues identified with the VFQ-25 included disordered response thresholds (12/26 items), local dependency (39/325 pairwise dependencies), and evidence of scale multidimensionality. However, no items were misfitting, scale-to-sample targeting was adequate for the range of visual abilities, and scale reliability was good (person-separation index, 0.91). Multiple issues were identified with the subscale scoring system of the original VFQ-25. Stage 2 utilised the stage 1 evidence to revise the VFQ-25 into two separate subscales, measuring the domains ‘vision-related activity limitation’ [10 items] and ‘socioemotional functioning’ [9 items]. The revised VFQ-25 demonstrated improved psychometric performance with both subscales operating well, displaying no disordered thresholds or misfitting items, excellent scale-to-sample targeting, acceptable scale reliability, and importantly, evidence of scale unidimensionality.

Conclusions : The original VFQ-25 performs better when split into two separate scales: vision-related activity limitation and socioemotional functioning. These scales possess valid parameters for assessment of the impact of vision loss due to LHON.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×