June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Small extracellular vesicles as a tool for retinal ganglion cell neuroprotection
Author Affiliations & Notes
  • Stanislav Tomarev
    Section of Retinal Ganglion Cell Biology, National Eye Institute, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Stanislav Tomarev NEI, 11058729, Code P (Patent)
  • Footnotes
    Support  Supported by the Intramural Research Programs of the National Eye Institute (Bethesda, MD, USA)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1941. doi:
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    • Get Citation

      Stanislav Tomarev; Small extracellular vesicles as a tool for retinal ganglion cell neuroprotection. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1941.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : The presentation will describe how small extracellular vesicles (sEVs) were used for retinal ganglion cell neuroprotection. sEVs were isolated from human mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells by differential centrifugation with subsequent fractionated by density gradient centrifugation. The composition and neuroprotective properties of individual fractions of sEVs were compared with unfractionated sEVs. Neuroprotective experiments were performed using in vitro and in vivo rodent models. The neuroprotective effect of sEVs, at least partially, may be explained by direct action on retinal ganglion cells through miRNA-dependent mechanisms.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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