June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Retinal vein occlusion as a potential independent marker of incident dementia in a Danish national cohort.
Author Affiliations & Notes
  • Anna Rebien Clausen
    Department of Ophthalmology, Odense Universitetshospital, Odense, Syddanmark, Denmark
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Lonny Stokholm
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
    OPEN - Open Patient data Explorative Network, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Morten Blaabjerg
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
    Department of Neurology, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Katrine Hartmund Frederiksen
    Department of Ophthalmology, Odense Universitetshospital, Odense, Syddanmark, Denmark
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Frederik Pedersen
    Department of Ophthalmology, Odense Universitetshospital, Odense, Syddanmark, Denmark
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Jakob Grauslund
    Department of Ophthalmology, Odense Universitetshospital, Odense, Syddanmark, Denmark
    Department of Clinical Research, Odense Universitetshospital, Odense, Syddanmark, Denmark
  • Footnotes
    Commercial Relationships   Anna Clausen None; Lonny Stokholm None; Morten Blaabjerg None; Katrine Frederiksen None; Frederik Pedersen None; Jakob Grauslund None
  • Footnotes
    Support  The VELUX Foundation, Grant 00051094
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1782. doi:
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      Anna Rebien Clausen, Lonny Stokholm, Morten Blaabjerg, Katrine Hartmund Frederiksen, Frederik Pedersen, Jakob Grauslund; Retinal vein occlusion as a potential independent marker of incident dementia in a Danish national cohort.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1782.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Retinal vein occlusion (RVO) is a common cause of loss of vision. As the retina and the brain share embryologic origin, retinal vascular occlusions may reflect the initial signs of cerebral dysfunction. As early detection of patients in risk of dementia could allow for preventive treatment, the aim of this study was to investigate RVO as an independent biomarker of incident dementia.

Methods : In a nationwide, longitudinal cohort study, we identified 3,115,898 participants through the Danish national health registries. We included individuals above 55 years, as identified between 1 January 1998 and 31 December 2016 and followed the cohort until 31 December 2018. We excluded individuals if they had a registration of RVO, unspecified retinal vascular occlusion, or any dementia prior to entry date. We calculated incidence rate (IR) and performed a Cox regression analysis with hazard ratios (HR) and 95 % confidence intervals (CI) for RVO (exposure) as a marker of all-cause dementia, vascular dementia, and Alzheimer’s disease from a crude model and a model adjusted for age, sex, marital status and systemic comorbidity.

Results : We identified 13,911 individuals with RVO, who were more likely to have hypertension, chronic kidney disease, and dyslipidemia compared to those unexposed with RVO (n=3,083,564, p<0.001). IR of all-cause dementia was 7.1 and 3.1 per 1000 person-years at risk (PYR) in individuals exposed to RVO (578 of 81,169 PYR) and those without RVO (104,194 of 33,212,707 PYR). In the crude and adjusted model for all-cause dementia, RVO was not associated with upcoming dementia (crude HR 1.08, 95 % CI 1.00-1.18 and adjusted HR 1.01 95 % CI 0.93-1.09). Likewise, RVO did not independently predict Alzheimer’s disease (adjusted HR 0.93, 95 % CI 0.82-1.05), nor vascular dementia (adjusted HR 1.09, 95 % CI 0.87-1.36).

Conclusions : Individuals with RVO had no higher risk of incident all-cause dementia, Alzheimer’s disease, or vascular dementia compared to individuals not exposed with RVO in a nationwide cohort.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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