June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
A Self-contained Intraocular Implant to Bypass Corneal Opacity
Author Affiliations & Notes
  • Supriyo Sinha
    Twenty/Twenty Therapeutics, South San Francisco, California, United States
  • Kyle Gilpin
    Twenty/Twenty Therapeutics, South San Francisco, California, United States
  • VanDee Moua
    Twenty/Twenty Therapeutics, South San Francisco, California, United States
  • Dimitri T Azar
    Twenty/Twenty Therapeutics, South San Francisco, California, United States
    Ophthalmology, University of Illinois Chicago College of Medicine, Chicago, Illinois, United States
  • Charles Q Yu
    Stanford University School of Medicine, Stanford, California, United States
  • Footnotes
    Commercial Relationships   Supriyo Sinha Twenty/Twenty Therapeutics, Code E (Employment), Twenty/Twenty Therapeutics, Code P (Patent); Kyle Gilpin Twenty/Twenty Therapeutics, Code E (Employment); VanDee Moua Twenty/Twenty Therapeutics, Code E (Employment); Dimitri Azar Twenty/Twenty Therapeutics, Code O (Owner), Twenty/Twenty Therapeutics, Code P (Patent); Charles Q Yu Stanford University, Code E (Employment)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1735. doi:
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    • Get Citation

      Supriyo Sinha, Kyle Gilpin, VanDee Moua, Dimitri T Azar, Charles Q Yu; A Self-contained Intraocular Implant to Bypass Corneal Opacity. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1735.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Corneal opacity is the second most common cause of reversible blindness after cataracts. The current standard of care is corneal transplantation. However, fundamental limitations, such as limited supply of donor corneas and graft rejection, leave many patients blind. There are over 12 million patients on cornea transplant waitlists. We have designed an intraocular implant that can overcome these fundamental limitations by electronically bypassing the cornea. We have demonstrated a proof-of-concept of this device on the benchtop.

Methods : We designed an implant that contains a laser and scanning system to project images onto the retina. The implant is to be surgically implanted in the lens capsule of the eye. Power and data is transmitted wirelessly to the implant via a pair of glasses that houses a battery and a camera imaging system. The first generation device is designed to produce single color greyscale images and supports 640x480 resolution with a field of view of 45 degrees and 30 degrees in the horizontal and vertical axes, respectively.
We have completed a benchtop optical system that demonstrates proof of concept. Custom miniaturized optical components suitable for a final 10-mm diameter system were designed and fabricated. All optical elements were placed on a high-resolution 3-D printed scaffold. Prototype electronics to transmit and receive data and power were designed and built and successfully generated a properly synchronized image.

Results : Our benchtop system successfully displayed images at 320x240 resolution with 30 fps refresh rate. The images had 4-bit color depth and were projected in focus at a distance similar to the lens capsule to retina spacing. The electrical power to drive the illumination system at maximum brightness is less than 10 mW. Power consumption of the scanning mirror system is less than 100 mW. The tetherless system successfully received power and data through two separate antennas.

Conclusions : We have completed a benchtop demonstration of an electronic implant to bypass cornea opacity. This provides a technological solution to corneal blindness that overcomes the current limitations of transplantation.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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