June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The effect of gaze contingency on mfERGs
Author Affiliations & Notes
  • Alison Taylor
    New England College of Optometry, Boston, Massachusetts, United States
  • Sara Aghajari
    New England College of Optometry, Boston, Massachusetts, United States
  • Fuensanta A Vera-Diaz
    New England College of Optometry, Boston, Massachusetts, United States
  • Peter J Bex
    Northeastern University College of Science, Boston, Massachusetts, United States
  • Athanasios Panorgias
    New England College of Optometry, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Alison Taylor None; Sara Aghajari None; Fuensanta Vera-Diaz Vyluma, Essilor, Coopervision, Code C (Consultant/Contractor), Vyluma, Essilor, Coopervision, Meta Reality Labs, , Code F (Financial Support); Peter Bex PerZeption, Adaptive Sensory technology, Code I (Personal Financial Interest), PerZeption, Adaptive Sensory Technology, Code O (Owner), Northeastern University, Mass Eye and Ear, Code P (Patent); Athanasios Panorgias None
  • Footnotes
    Support  1R21EY031085-01 (PI: Panorgias)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1635. doi:
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      Alison Taylor, Sara Aghajari, Fuensanta A Vera-Diaz, Peter J Bex, Athanasios Panorgias; The effect of gaze contingency on mfERGs. Invest. Ophthalmol. Vis. Sci. 2023;64(8):1635.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A custom-built gaze-contingent mfERG system, created to improve spatial specificity by correcting for eye movements, was evaluated with and without gaze-contingency in a group of healthy subjects.

Methods : Eight subjects participated (age 24.6±2.2 years, mean±1SD). An ocular health questionnaire was administered and vision tests conducted to ensure no ocular abnormalities or systemic diseases that affect vision. The mfERG stimulus was generated using Psychtoolbox interfaced with a BITS# stimulus generator (CRS LTD). The stimulus was a 3x3 grid of squares (15x15deg) presented on an LCD monitor (LG) based on a 14-bit m-sequence. An EyeLink eye tracker continuously recorded the subject’s eye movements during the recordings. Each subject participated in a “Fixed” recording, where the stimulus’ location on the screen was fixed, and a “GC” recording, where the stimulus was gaze-contingent. Signal-to-noise ratio (SNR) calculations were performed to assess the quality of the recordings. Eye movements and amplitudes for the N1 and P1 components were extracted from the recordings to be analyzed. For analysis purposes, the stimulus was categorized into a central section (central square only, central 5deg), and a peripheral section (the remaining squares).

Results : SNR calculations indicated good reliability and did not show significant differences in quality between the two conditions (t=0.97, p=0.34). Traces with SNR<1.5 were excluded from the analysis (5 of 72 pairs). The average extent of eye movements during the recordings was 0.89deg±0.29 horizontally and 1.46deg±0.50 vertically. Bland-Altman plots for P1 amplitudes show no significant mean difference between the conditions (p>0.05) for either the central or peripheral squares of the stimuli. Bland-Altmann plots for N1 amplitudes showed no significant differences between the conditions for the central square (t=0.79, p=0.46), however, the N1 amplitudes of the peripheral squares in the “Fixed” condition are significantly higher than the “GC” condition (t=2.14, p=0.037).

Conclusions : SNR analysis shows that the custom-built system is able to achieve good-quality recordings with gaze correction. The higher N1 amplitudes in the periphery during the “Fixed” condition might indicate poor spatial specificity. The peripheral squares may be exciting areas of higher cone density during eye movements, as opposed to the “GC” condition where the stimuli are fixed on specific retinal locations.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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