Abstract
Presentation Description :
Fibroblast growth factors are key drivers of the growth and development of the cornea. A modified version of fibroblast growth factor 1 (TTHX1114) has been developed that can protect endothelial cells from death, stimulate proliferation in these normally quiescent cells, and drive regeneration. This drug causes endothelial cells to proliferate in both normal and dystrophic corneas. Clinical studies show that TTHX1114 accelerates visual recovery after ocular surgery. The regenerated endothelial cells are morphologically and phenotypically normal. TTHX1114 may have utility in the treatment of endothelial diseases and injury.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.