June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Higher Aqueous Levels of Vascular Cell Adhesion Molecule-1 (VCAM-1) Is Related to Macular Fibrosis in Neovascular Age-related Macular Degeneration
Author Affiliations & Notes
  • Wen Deng
    Aier School of Ophthalmology, Central South University, Changsha, China
    Aier Institute of Optometry and Vision Science, Changsha, China
  • Juan Chen
    Changsha Aier Eye Hospital, Changsha, China
  • Wei Pan
    Aier Institute of Optometry and Vision Science, Changsha, China
  • Jian Liu
    Aier Institute of Optometry and Vision Science, Changsha, China
  • Caijiao Yi
    Aier Institute of Optometry and Vision Science, Changsha, China
  • Zengchao Zhou
    Changsha Aier Eye Hospital, Changsha, China
  • Yiqin Duan
    Changsha Aier Eye Hospital, Changsha, China
  • Xiangyan Ning
    Changsha Aier Eye Hospital, Changsha, China
  • Jun Li
    Changsha Aier Eye Hospital, Changsha, China
  • Jianbo Wan
    Changsha Aier Eye Hospital, Changsha, China
  • Dan Zhou
    Changsha Aier Eye Hospital, Changsha, China
  • Changhua Ye
    Aier School of Ophthalmology, Central South University, Changsha, China
    Changsha Aier Eye Hospital, Changsha, China
  • Zhongping Chen
    Aier School of Ophthalmology, Central South University, Changsha, China
    Changsha Aier Eye Hospital, Changsha, China
  • Heping Xu
    Aier School of Ophthalmology, Central South University, Changsha, China
    Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast BT9 7BL, United Kingdom
  • Footnotes
    Commercial Relationships   Wen Deng None; Juan Chen None; Wei Pan None; Jian Liu None; Caijiao Yi None; Zengchao Zhou None; Yiqin Duan None; Xiangyan Ning None; Jun Li None; Jianbo Wan None; Dan Zhou None; Changhua Ye None; Zhongping Chen None; Heping Xu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2204. doi:
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      Wen Deng, Juan Chen, Wei Pan, Jian Liu, Caijiao Yi, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Jianbo Wan, Dan Zhou, Changhua Ye, Zhongping Chen, Heping Xu; Higher Aqueous Levels of Vascular Cell Adhesion Molecule-1 (VCAM-1) Is Related to Macular Fibrosis in Neovascular Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2204.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the aqueous levels of adhesion molecules ICAM-1, VCAM-1,CD44, CD62L and CD62P in neovascular age-related macular degeneration (nAMD) patients and the link between intraocular levels of adhesion molecules and clinical presentations, including the response to anti-VEGF therapy.

Methods : Forty-eight nAMD patients including 24 with choroidal neovascularisation (CNV) and 24 with polypoidal choroidal vasculopathy (PCV), and age-matched 24 cataract patients (as controls) were recruited to this study. Half of the CNV and PCV patients had macular fibrosis and the other half did not. Retinal lesions were examined by fundus colour photography and optical coherence tomographic angiography . Approximately 100μL of aqueous humor was collected during intravitreal anti-VEGF injection or cataract surgery. The aqueous levels of ICAM-1, VCAM-1, CD44, CD62L and CD62P were measured using the Luminex multiplex assay. The relationship between adhesion molecules levels and clinical presentations was analysed by Pearson correlation test.

Results : The aqueous levels of ICAM-1, VCAM-1, CD44 and CD62L were significantly higher in nAMD compared to controls. Further analysis of nAMD subgroups showed that the levels of these adhesion molecules were significantly higher in both CNV and PCV patients. Interestingly, the aqueous level of VCAM-1 was significantly higher in nAMD with macular fibrosis but not in patients without macular fibrosis. The levels of ICAM-1, CD44 and CD62L were significantly increased in nAMD patients regardless of macular fibrosis although the increment was more pronounced in patients with macular fibrosis. The aqueous level of VCAM-1 correlated positively with the Central Retinal Thickness (CRT); whereas the intraocular level of ICAM-1 correlated negatively with the CRT reduction in nAMD patients. No correlation was observed between any of the adhesion molecules and visual acuity or the number of intravitreal anti-VEGF injections.

Conclusions : Our results suggest that nAMD patients (CNV and PCV), especially those with macular fibrosis, had higher aqueous levels of ICAM-1, VCAM-1, CD44 and CD62L. Intraocular level of VCAM-1 may be a valuable biomarker to distinguish patients with macular fibrosis from those without. Our results also suggest that these adhesion molecules may be involved in the development of macular fibrosis in nAMD patients.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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