June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Choroidal vascular brightness intensity and treatment outcomes in polypoidal choroidal vasculopathy: ultra-widefield indocyanine green angiography study
Author Affiliations & Notes
  • Areum Jeong
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Seung Chul Baek
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Heejeon Yoon
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Chaewon Lim
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Sooncheol Cha
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Min Sagong
    Ophthalmology, Yeungnam University Medical Center, Daegu, Daegu, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Areum Jeong None; Seung Chul Baek None; Heejeon Yoon None; Chaewon Lim None; Sooncheol Cha None; Min Sagong None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2165. doi:
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      Areum Jeong, Seung Chul Baek, Heejeon Yoon, Chaewon Lim, Sooncheol Cha, Min Sagong; Choroidal vascular brightness intensity and treatment outcomes in polypoidal choroidal vasculopathy: ultra-widefield indocyanine green angiography study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2165.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate choroidal vascular brightness intensity using ultra-widefield indocyanine green angiography (UWF ICGA) images of polypoidal choroidal vasculopathy (PCV) and to analyze its association with treatment outcomes.

Methods : A review of the medical records of treatment naïve subfoveal PCV patients who received intravitreal anti-VEGF injection was conducted. Choroidal vascular brightness intensity was measured by extracting enhanced pixels of choroidal vessels after adjusting the reference brightness across the images to be the same. The distribution of choroidal vascular brightness intensity, subfoveal choroidal thickness (SFCT), dry macula after loading phase, and the proportion of subjects with a gain of 15 or more letters from baseline best-corrected visual acuity letter score were evaluated. The relationship between choroidal vascular brightness intensity and treatment outcomes was analyzed. Receiver-operating characteristic (ROC) curves analysis was performed to compare the predictive performance of choroidal vascular density (CVD) and choroidal vascular brightness intensity.

Results : Forty-two eyes of 42 patients with PCV were included in this study. The choroidal vascular brightness intensity was higher at the posterior than that of the periphery, and the inferior quadrants were brighter than the superior quadrants. Increased choroidal vascular brightness intensity from the posterior pole was more significantly associated with thicker SFCT, higher dry rate after loading injections, and more 3-line gainers at 12 months, when compared to that of periphery. In the multiple regression analysis, fluid resolution after loading injections and 3-line gainer at 12 months were significantly associated with thin SFCT (p=0.020, p=0.016), and decreased CVD (p=0.012, p=0.010) and choroidal vascular brightness intensity (p=0.004, p=0.005). The choroidal vascular brightness intensity had higher area under curve than CVD for fluid resolution after loading injections (AUC=0.828, AUC=0.648) and 3-line gainer at 12 months (AUC=0.805, AUC=0.606).

Conclusions : Choroidal vascular brightness intensity suggesting venous outflow congestion can be used as a new biomarker in predicting treatment outcomes in PCV.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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