June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Lamellar Macular Hole Surgery: Anatomical and Functional Outcomes
Author Affiliations & Notes
  • Yosra Er-reguyeg
    Universite Laval Faculte de medecine, Quebec, Quebec, Canada
  • Sihame Doukkali
    Universite Laval Faculte de medecine, Quebec, Quebec, Canada
  • Mélanie Hébert
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Eunice You
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Serge Bourgault
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Mathieu Caissie
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Éric Tourville
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Ali Dirani
    Hopital du Saint-Sacrement, Quebec, Quebec, Canada
  • Footnotes
    Commercial Relationships   Yosra Er-reguyeg None; Sihame Doukkali None; Mélanie Hébert None; Eunice You None; Serge Bourgault None; Mathieu Caissie None; Éric Tourville None; Ali Dirani None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2913. doi:
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      Yosra Er-reguyeg, Sihame Doukkali, Mélanie Hébert, Eunice You, Serge Bourgault, Mathieu Caissie, Éric Tourville, Ali Dirani; Lamellar Macular Hole Surgery: Anatomical and Functional Outcomes. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2913.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study is to analyze the anatomical and functional results of lamellar macular hole surgery and to assess in which lamellar macular hole cases the surgery has the best prognosis.

Methods : A retrospective observational study was conducted on 97 patients operated for unilateral lamellar macular hole (LMH) between 2014 and 2021 at the CUO-CHU de Quebec - Université Laval. Patient that had less than 3 months of follow-up were excluded. The primary outcome was final postoperative best-corrected visual acuity (BCVA). Preoperative characteristics, surgical modalities, and optical coherence tomographies (OCT) findings were also collected. A multiple linear regression model was used to assess which variables were predictive of final BCVA.

Results : 63 of the 97 patients (64.9%) presenting a LMH were women and 34 were men (35.1%). Mean age at surgery was 70±9 years. Most patients (n=93, 95.9%) also had a concomitant epiretinal membrane (ERM) at the initial presentation. Eleven patients (11.3%) had a dry age-related macular degeneration (AMD). All the patients underwent 25-gauge pars plana vitrectomy (PPV) (n=97,100%), with most (n=78, 80.4%) undergoing concurrent ERM and internal limiting membrane (ILM) peel. Most patients (n=62, 63.9%) had SF6 gas as tamponade agent. There was a 89.7% (n=87) success rate of postoperative LMH closure. A significant difference was observed between median [Q1, Q3] preoperative BCVA (0.42 [0.26, 0.61]) and final BCVA (0.31 [0.14, 0.49]) (p=0.023). All preoperative variables were evaluated through a multiple linear regression model. The model has suggested that gender (β=0.223; p=0,017), age at presentation (β=0.246; p=0.013), SF6 gas tamponade (β=0.211; p=0.025), preoperative ERM (β=-0.233; p=0.013) and history of AMD (β=0.275; p=0.004) were the predictors of final BCVA.

Conclusions : Results indicate that LMH surgery improves patients’ visual acuity. OCT imaging has shown that macular defects tend to decrease postoperatively. Masculine sex, older age, presence of AMD and use of SF6 gas tamponade are factors associated with poorer final BCVA. On the other hand, the presence of a preoperative ERM resulted in better final BCVA. Compared to prior reports on the subject, our sample size is one of the largest.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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