June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Longitudinal changes of retinal ganglion cell function in optic pathway glioma evaluated by photopic negative response.
Author Affiliations & Notes
  • Dario Marangoni
    Department of Medicine, Surgery and Health Sciences, Universita degli Studi di Trieste, Trieste, Friuli-Venezia Giulia, Italy
  • Giorgio Placidi
    NeuroScience, Sensory Organs and Chest, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Elena D'Agostino
    NeuroScience, Sensory Organs and Chest, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Elisa De Siena
    NeuroScience, Sensory Organs and Chest, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Bruno Imbimbo
    Research & Development, Chiesi Farmaceutici SpA, Parma, Emilia-Romagna, Italy
  • Giorgio Attina'
    Women, children and public health sciences, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Stefano Mastrangelo
    Women, children and public health sciences, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Antonio Ruggiero
    Women, children and public health sciences, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Benedetto Falsini
    NeuroScience, Sensory Organs and Chest, Universita Cattolica del Sacro Cuore Facolta di Medicina e Chirurgia, Roma, Lazio, Italy
  • Footnotes
    Commercial Relationships   Dario Marangoni None; Giorgio Placidi None; Elena D'Agostino None; Elisa De Siena None; Bruno Imbimbo None; Giorgio Attina' None; Stefano Mastrangelo None; Antonio Ruggiero None; Benedetto Falsini None
  • Footnotes
    Support  Grant Ministero della Salute RF2019 #12369119
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2897. doi:
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      Dario Marangoni, Giorgio Placidi, Elena D'Agostino, Elisa De Siena, Bruno Imbimbo, Giorgio Attina', Stefano Mastrangelo, Antonio Ruggiero, Benedetto Falsini; Longitudinal changes of retinal ganglion cell function in optic pathway glioma evaluated by photopic negative response.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2897.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A previous study demonstrated that the photopic negative response (PhNR), a component of the flash electroretinogram that reflects retinal ganglion cell (RGC) function, is significantly impaired in patients affected by optic pathway glioma (OPG). The aim of this longitudinal study was to evaluate whether PhNR deteriorates over time in patients with OPG.

Methods : Fourteen pediatric patients affected by OPG (4 males and 10 females, mean age 12.4 ± 4.6 years, 8 with NF1) with ≥ 12 months of follow-up and 3 evaluations, were included in this retrospective study. At baseline, all patients underwent a complete ophthalmological examination. Follow-up included clinical examination and PhNR measurements as well as brain MRI (according to pediatric oncologist indications) every 6 or 12 months. Mean follow-up duration was 17.1 ± 7.4 months (range 12-36 months).
Photopic electroretinograms were elicited by 2 cd/m2 Ganzfeld white flashes presented on a steady 20 cd/m2 white background.The PhNR amplitude was measured as the difference between baseline and the maximal negative amplitude (minimum) of the negative wave, following the photopic b-wave.

Results : Compared to baseline values, PhNR amplitude was significantly decreased at the end of follow-up (from 9.1 ± 3.0 mV to 7.8 ± 3.0 mV, p = 0.02). No significant changes were noted in PhNR latency, B-wave amplitude and latency. During the follow-up, a significant worsening (below 95% test-retest variability) of PhNR amplitude occurred in 6 patients (43%) while in the remaining 8 patients (57%) PhNR remained stable. None of the patients had a significant PhNR improvement. MRI showed no changes in tumor size in all patients.

Conclusions : Mean PhNR amplitude decreased significantly at the end of follow-up relative to baseline values, suggesting progressive RGC dysfunction in OPG. PhNR may represent a non-invasive and objective probe of progressive RGC dysfunction in the clinical management of childhood OPG.


Abed E, Piccardi M, Rizzo D, Chiaretti A, Ambrosio L, Petroni S, Parrilla R, Dickmann A, Riccardi R, Falsini B. Functional Loss of the Inner Retina in Childhood Optic Gliomas Detected by Photopic Negative Response. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2469-74.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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