June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Prevalence of Dry Eyes in Patients with Common Neurological, Musculoskeletal, and Rheumatological Conditions – A Study Using the Sight Outcomes Research Collaborative (SOURCE) Repository
Author Affiliations & Notes
  • Alex Valentine
    University of Michigan W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Kennedy Depperschmidt
    Ocular Therapeutix Inc, Bedford, Massachusetts, United States
  • Matthew Callewaert
    Ocular Therapeutix Inc, Bedford, Massachusetts, United States
  • An Hong Su
    University of Michigan W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Joshua D Stein
    University of Michigan W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Footnotes
    Commercial Relationships   Alex Valentine None; Kennedy Depperschmidt Ocular Therapeutix Inc, Code E (Employment); Matthew Callewaert Ocular Therapeutix Inc, Code E (Employment); An Hong Su None; Joshua Stein Ocular Therapeutix Inc, Janssen, Abbvie, Code F (Financial Support)
  • Footnotes
    Support  NEI R01 EY032475; NIA R01 AG07258201; Ocular Therapeutix Grant
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2879. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alex Valentine, Kennedy Depperschmidt, Matthew Callewaert, An Hong Su, Joshua D Stein; Prevalence of Dry Eyes in Patients with Common Neurological, Musculoskeletal, and Rheumatological Conditions – A Study Using the Sight Outcomes Research Collaborative (SOURCE) Repository. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2879.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : A variety of neurological, musculoskeletal, and rheumatological conditions can predispose patients to dry eyes. Management of dry eyes in patients with these conditions can be difficult because often the underlying disease limits the ability for patients to self-administer lubricating eye drops.

Methods : We identified all patients age ≥18 years old receiving care at 6 health systems participating in the Sight Outcomes Research Collaborative (SOURCE) repository. SOURCE captures EHR data on all eye care recipients at these institutions. We identified patients in SOURCE with dry eyes based on ICD billing codes, clinical exam findings consistent with dry eyes, and receipt of interventions for dry eyes. We assessed the extent by which these patients had common neurological, musculoskeletal, or rheumatological conditions that may make it difficult to self-administer ocular lubricants. Logistic regression assessed for potential associations between these medical conditions and dry eyes, adjusting for patient demographics and other factors.

Results : Of the 1446229 eligible patients in SOURCE, 321941 (22.3%) had evidence of dry eyes and among these, 156317 (48.6%) had ≥1 medical comorbidities that can make it difficult to administer lubricating eye drops. The proportion of patients with dry eyes with 1, 2, 3, 4+ impairments was 21.4%, 16.9%%, 6.8%, and 3.4%, respectively. After adjusting for sociodemographic factors, patients with ≥1 impairment that can limit eye drop instillation had 62% increased odds of dry eyes (adjusted odds ratio (aOR): 1.62 (1.61, 1.64)) compared to those with no impairments. Patients with 2 (aOR: 1.72 (1.70, 1.74), 3 (aOR: 2.16 (2.12, 2.20), 4+ (aOR: 2.48 (2.42, 2.55) impairments had a 72%, 116%, and 148% increased odds of dry eyes, respectively, compared to those with no impairments.

Conclusions : Nearly 50% of patients with dry eyes had one or more medical conditions that may make it challenging to self-administer lubricating eye drops. These patients may benefit from alternative treatments to help with ocular surface lubrication.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×