June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Correlation of structural biomarkers to fundus-controlled perimetry in intermediate age-related macular degeneration: a seven-year longitudinal study
Author Affiliations & Notes
  • Marlene Sassmannshausen
    Ophthalmology, University Bonn, Germany
  • Senem Döngelci
    Ophthalmology, University Bonn, Germany
  • Marc Vaisband
    Institute for Mathematics and Life Science,, University Bonn, Bonn, Germany
  • Leon Alexander von der Emde
    Ophthalmology, University Bonn, Germany
  • Kenneth R Sloan
    Department of Computer Science,, The University of Alabama at Birmingham College of Arts and Sciences, Birmingham, Alabama, United States
  • Jan Hasenauer
    Institute for Mathematics and Life Science,, University Bonn, Bonn, Germany
  • Frank G Holz
    Ophthalmology, University Bonn, Germany
  • Thomas Ach
    Ophthalmology, University Bonn, Germany
  • Footnotes
    Commercial Relationships   Marlene Sassmannshausen Heidelberg Engineering, Zeiss MediTec, CenterVue , Code F (Financial Support), Nidek, Code R (Recipient); Senem Döngelci None; Marc Vaisband None; Leon von der Emde None; Kenneth Sloan None; Jan Hasenauer None; Frank Holz Acucela, Alexion, Alzheon, Allergan, Apellis, Astellas, Bayer, Boehringer-Ingelheim, Bioeq/Formycon, Roche/Genentech, Geuder, Graybug, Gyroscope, Heidelberg Engineering, IvericBio, Janssen, Kanghong, LinBioscience, Novartis, Oxurion, Pixium Vision, Oxurion, Stealth BioTherapeutics, Zeiss, Code C (Consultant/Contractor), Acucela, Allergan, Apellis, Bayer, Bioeq/Formycon, CenterVue, Roche/Genentech, Geuder, Heidelberg Engineering, IvericBio, NightStarX, Novartis, Optos, Pixium Vision, Oxurion, Zeis, Code F (Financial Support), GRADE Reading Center, Code O (Owner); Thomas Ach Roche, Novartis, Apellis, Bayer, Nidek , Code C (Consultant/Contractor), Novartis, Nidek , Code R (Recipient)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2766. doi:
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      Marlene Sassmannshausen, Senem Döngelci, Marc Vaisband, Leon Alexander von der Emde, Kenneth R Sloan, Jan Hasenauer, Frank G Holz, Thomas Ach; Correlation of structural biomarkers to fundus-controlled perimetry in intermediate age-related macular degeneration: a seven-year longitudinal study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2766.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To longitudinally correlate presence of structural biomarkers and changes of retinal morphology to spatially resolved retinal sensitivity assessments by mesopic and scotopic fundus-controlled perimetry (FCP) in patients with intermediate age-related macular degeneration (iAMD).

Methods : 68 eyes of 62 patients (mean±SD: 77.8±8.5 years) with large drusen (>125µm) secondary to iAMD and 29 eyes of 29 age-matched healthy controls were included. Annual visits were performed over 7 years. Participants underwent multimodal retinal imaging including spectral domain optical coherence tomography (SD-OCT, volume: 30°x25°, 61 B-scans) as well as mesopic and scotopic FCP (56-stimulus grid: MP-1S, Nidek). At each FCP stimuli position and visit, presence of structural biomarkers was computer-assisted manually graded (including sub-retinal pigment epithelium (sub-RPE) drusen, subretinal drusenoid deposits (SDDs), hyperreflective foci (HRF), incomplete/complete retinal pigment epithelium and outer retinal atrophy (i/cRORA)) and spatially resolved retinal layer thicknesses extracted using an ImageJ plugin. Mixed effect models were applied analyzing the association of structural biomarkers and retinal layer thickness changes with mesopic/scotopic sensitivity losses.

Results : Over a 7-year observation period there was an overall mean loss of retinal sensitivity of –2.83dB for mesopic and –1.95dB for scotopic testing. Decline was more pronounced for scotopic than mesopic sensitivity in presence of SDDs and sub-RPE drusen (scotopic:estimate:-0.97dB; p=0.0005, mesopic:-0.53dB; p=0.016) compared to study eyes with sub-RPE drusen only (scotopic:+0.05dB; p=0.50 and mesopic:-0.13dB; p=0.03). Presence of HRF had a stronger correlation to mesopic (-0.83dB; p<0.001) than scotopic testing (-0.06dB; p=0.014). A similar correlation was found at FCP positions with atrophy development (mesopic:-0.86dB;p<0.001(iRORA) and -0.86dB;p=0.003 (cRORA) vs. scotopic: -0.11dB;p<0.001 and -0.24dB;p<0.001). With decreasing outer photoreceptor layer thicknesses (OS), sensitivity losses were even higher for scotopic than for mesopic testing (-0.08dB;p<0.001 (scotopic) and -0.006dB;p=0.659 (mesopic)).

Conclusions : Presence of SD-OCT based structural biomarkers and retinal layers thickness changes significantly impact longitudinal spatially resolved mesopic and scotopic retinal function in iAMD.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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