June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Correlation of advanced glycation end products with retinal parameters measured with OCTA in diabetic patients
Author Affiliations & Notes
  • Beate Peterfelde
    Faculty of Medicine, Latvijas Universitate, Riga, Riga, Latvia
    Department of Ophthalmology, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia
  • Dace Petersone
    Faculty of Physics, Mathematics and Optometry, Latvijas Universitate, Riga, Riga, Latvia
  • Zane Svikle
    Faculty of Medicine, Latvijas Universitate, Riga, Riga, Latvia
  • Renate Nagobade
    Faculty of Medicine, Latvijas Universitate, Riga, Riga, Latvia
    Department of Ophthalmology, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia
  • Eliza Briede
    Latvijas Universitate, Riga, Riga, Latvia
    Department of Ophthalmology, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia
  • Kristina Agiseva
    Department of Ophthalmology, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia
  • Janis Valeinis
    Faculty of Physics, Mathematics and Optometry, Latvijas Universitate, Riga, Riga, Latvia
  • Jelizaveta Sokolovska
    Faculty of Medicine, Latvijas Universitate, Riga, Riga, Latvia
  • Kristine Baumane
    Faculty of Medicine, Latvijas Universitate, Riga, Riga, Latvia
    Department of Ophthalmology, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia
  • Footnotes
    Commercial Relationships   Beate Peterfelde EEA-RESEARCH-60, Code F (Financial Support); Dace Petersone EEA-RESEARCH-60, Code F (Financial Support); Zane Svikle EEA-RESEARCH-60, Code F (Financial Support); Renate Nagobade EEA-RESEARCH-60, Code F (Financial Support); Eliza Briede None; Kristina Agiseva None; Janis Valeinis EEA-RESEARCH-60, Code F (Financial Support); Jelizaveta Sokolovska EEA-RESEARCH-60, Code F (Financial Support); Kristine Baumane EEA-RESEARCH-60, Code F (Financial Support)
  • Footnotes
    Support  Acknowledgement. The work was supported by the Baltic Research Programme of the European Economic Area (EEA) grants, project Integrated model for personalized diabetic retinopathy screening and monitoring using risk-stratification and automated AI-based fundus image analysis (PerDiRe).
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2556. doi:
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      Beate Peterfelde, Dace Petersone, Zane Svikle, Renate Nagobade, Eliza Briede, Kristina Agiseva, Janis Valeinis, Jelizaveta Sokolovska, Kristine Baumane; Correlation of advanced glycation end products with retinal parameters measured with OCTA in diabetic patients. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2556.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to evaluate the association of the degree of diabetic retinopathy in type 1 (T1D) and type 2 (T2D) diabetes patients with advanced glycation end products (AGEs) and retinal parameters assessed by optical coherence tomography angiography (OCTA).

Methods : A single-centre prospective cross-sectional study included 95 eyes of 95 patients (female 73.7%; median age 65 years (49.0-71.5); median diabetes duration 15 years (8.0-25.0)) with T1D (36.8%) and T2DM (63.2%). Exclusion criteria were significant chronic systemic or ocular diseases other than diabetes. The subjects were divided into two groups: without DR and with DR. OCTA (Optovue Solix FullRange) images were processed to quantify foveal avascular zone (FAZ) area (mm2), macular vessel density (VD) in superficial (SCP) and deep (DCP) capillary plexus (%) and flow in the outer retina and choriocapillaris. AGEs risk groups (0-normal, 1- mild risk, 2- intermediate risk, 3- high risk) were determined using AGE reader (Diagnoptics). Statistical analysis was performed using Rstudio: Kruskal-Wallis, Wilcoxon, Fisher, Chi-square test.

Results : Median age was higher in the DR group- 57 years (42.0-67.0) compared to the group without DR- 70 years (53.3-74.8), p=0.0018. The group with DR had higher risk groups of AGEs than the group without DR (p<0.001). AGEs risk groups were advanced with longer duration of diabetes (p<0.001) and in the group with DR (p<0.001). There was a significant difference between the AGEs risk groups and:1) age of the subjects, p<0.001, and 2) VD at DCP, p=0.017. There was no significant association between the groups: no DR and DR: 1) mean FAZ area (all subjects 0.27 mm2), p=0.196); 2) VD at SCP (all subjects 46.8%, p=0.31); 3) VD in DCP (all subjects 50.4%, p=0.55). There was no significant correlation between the AGEs risk group and: 1) VD in SCP, p=0.23; 2) FAZ area, p=0.26; 3) flow in the outer retina, p=0.053 and choriocapillaris, p=0.22; 4) arterial blood pressure, p=0.76. There was no significant correlation between FAZ area and: 1) VD in SCP (r=-0.20); 2) VD in DCP (r=-0.14); 3) DR stage (p=0.20); 4) duration of diabetes (p=0.27).

Conclusions : Quantitative evaluation of retinal microvasculature and AGEs levels can be used as an non-invasive biomarkers of vascular health. Further research is needed to use these parameters as prognostic factors in the assesment of diabetic retinopathy.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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