June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Assessment of the relationship between presence of active retinal vasculitis and aqueous flare values using laser flare meter
Author Affiliations & Notes
  • Anh Ngoc Tram Tran
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Amir Akhavanrezayat
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Irmak Karaca
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Hassan Khojasteh
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Muhammad Sohail Halim
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
    Ocular Imaging Research and Reading Center, California, United States
  • Gunay Uludag
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • YongUn Shin
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Hashem Ghoraba
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Chris Or
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Muhammad Hassan
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Albert John Bromeo
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Prapatsorn Ongpalakorn
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Cigdem Yasar
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Vahid Bazojoo
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Diana V Do
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Quan Dong Nguyen
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Anh Tran None; Amir Akhavanrezayat None; Irmak Karaca None; Hassan Khojasteh None; Muhammad Sohail Halim Ocular Imaging Research and Reading Center, Code E (Employment); Gunay Uludag None; YongUn Shin None; Hashem Ghoraba None; Chris Or None; Muhammad Hassan Alumis, Code C (Consultant/Contractor); Albert John Bromeo None; Prapatsorn Ongpalakorn None; Cigdem Yasar None; Vahid Bazojoo None; Diana Do Kodiak, Code I (Personal Financial Interest), Allergan, Genentech, Kriya, Regeneron, Code S (non-remunerative); Quan Nguyen Belite Bio, Genentech, Kriya, Regeneron, Rezolute, Code S (non-remunerative)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3409. doi:
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      Anh Ngoc Tram Tran, Amir Akhavanrezayat, Irmak Karaca, Hassan Khojasteh, Muhammad Sohail Halim, Gunay Uludag, YongUn Shin, Hashem Ghoraba, Chris Or, Muhammad Hassan, Albert John Bromeo, Prapatsorn Ongpalakorn, Cigdem Yasar, Vahid Bazojoo, Diana V Do, Quan Dong Nguyen; Assessment of the relationship between presence of active retinal vasculitis and aqueous flare values using laser flare meter. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3409.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The existence of anterior segment involvement in patients with retinal vasculitis disease is controversial. Evaluating the degree of inflammation using an objective method to measure aqueous flare may be helpful. Therefore, we conducted a comparative case series study to assess the relationship between active retinal vasculitis and aqueous flare values using laser flare photometry.

Methods : Among patients diagnosed with retinal vasculitis based on wide-angle fluorescein angiography in a tertiary uveitis clinic from June 2018 to June 2021, those with available aqueous flare measurements using a laser flare meter (Kowa FM-700, Japan) were identified. A total of 17 eyes of nine patients with active retinal vasculitis and quantitative flare measurements were selected as a case group (Group 1). No anterior segment inflammation was noted clinically in patients with retinal vasculitis at the time of aqueous flare measurement. Twenty-nine eyes of 15 subjects with no known ocular disease with flare measurements were determined as a control group (Group 2). Mean values of aqueous flare measurements were compared between the two groups.

Results : The mean age of the patients with retinal vasculitis was 41.3±26.7 (range, 10.3-76.3) years, and four (44.4%) were female. The mean age of the subjects with no known ocular disease was 36.7±8.22 (range, 28.7-56.5) years, and seven (46.7%) were female. The means for age of Groups 1 and 2 were not significantly different. Median duration of retinal vasculitis was 31 (0-330.5) days at the time of flare measurement. Mean aqueous flare measurement was 11.1±5.04 (range, 2.2-37.4) in Group 1 and 3.97±2.63 (range, 1.0-16.4) in Group 2, demonstrating a statistically significant difference (p<0.001).

Conclusions : Laser flare photometry is able to detect subclinical anterior chamber inflammation in patients with active retinal vasculitis which may be beneficial in assisting clinicians to manage and monitor patients more comprehensively.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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