June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Predicting risk stratification in ophthalmology emergency department triage from patient-informed structured clinical features using machine learning: preliminary results
Author Affiliations & Notes
  • Mariane Melo
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
    Dem Dx ltd, United Kingdom
  • Camilo Brandão-de-Resende
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
    Dem Dx ltd, United Kingdom
  • Anish Jindal
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Yan Ning Neo
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Elsa Lee
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Alex Day
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Mariane Melo Dem Dx ltd, Code E (Employment); Camilo Brandão-de-Resende Dem Dx ltd, Code E (Employment); Anish Jindal None; Yan Ning Neo None; Elsa Lee Dem Dx ltd, Code C (Consultant/Contractor); Alex Day None
  • Footnotes
    Support  NIHR AI awards
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3056. doi:
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      Mariane Melo, Camilo Brandão-de-Resende, Anish Jindal, Yan Ning Neo, Elsa Lee, Alex Day; Predicting risk stratification in ophthalmology emergency department triage from patient-informed structured clinical features using machine learning: preliminary results. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3056.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A steady increase in the use of Ophthalmology services over the past 2 decades combined with a forecasted shortfall of trained ophthalmologists, make the optimisation of patient triage vital if delivery of care is to be maintained or improved.
The purpose of this project is to develop a Machine learning-driven algorithm to risk stratification support in Ophthalmologic Emergency department triage and evaluate its performance when compared with the performance of experienced emergency triage nurses.

Methods :
A dataset of structured presentation of 9,226 cases (with demographics, signs/symptoms, and discharge diagnoses) seen at Moorfields Eye Hospital A&E (October/2021-Jun/2022) were collected at the triage, analysed and merged with the outcomes discharged diagnoses and treatment. Discharge diagnoses were risk-stratified as elective, urgent and emergency by the consensus of three experienced A&E consultants. The dataset was divided into training (n=7856|85.2%), validation (n=685|7.4%), and test (n=685|7.4%) sets. We evaluated three ML models (decision tree|random forest|XGBoost) predicting the risk ss from presenting clinical data. The best model (maximum specificity with sensitivity>95%) on the validation set was selected for testing and comparison with triages performed by nurses in current practice.

Results : XGBoost showed superior performance (validation sensitivity=95.1%|specificity=33.1%|ROCAUC=0.776), and the features that increased predicted urgency by order of importance were short duration, red/injected eye, male gender, unilateral presentation, age<50, photophobia, and floaters.
In the test set, the model had the sensitivity of 94.9% (92.5%-96.7%), specificity of 28.0% (22.0%-34.5%), ROCAUC of 0.758.
Nurses had sensitivity of 95.6% (93.3%-97.2%, p=0.65 compared to model) and specificity 15.2% (10.6%-20.7%, p=0.004). The model reduced urgent referrals by 4.8%(3.2%-6.7%) compared to nurses.

Conclusions : Our model had comparable sensitivity and superior specificity to triage nurses, suggesting that the use of ML could enhance emergency care service utilisation. Further research is required to determine if ML could support triage nurses in their decision-making in the clinical setting.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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