June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Immediate effects of e-cigarette use on systemic cardiovascular outcomes and retinal perfusion as measured by OCT angiography: a pilot study
Author Affiliations & Notes
  • Sarah Alowedi
    Ophthalmology, Queen's University, Kingston, Ontario, Canada
  • Patrick Wang
    Ophthalmology, Queen's University, Kingston, Ontario, Canada
  • Yao Wang
    Ophthalmology, Eastern Health, St. John's, Newfoundland, Canada
  • Evan F Sharma
    Faculty of Health Science, Queen's University, Kingston, Ontario, Canada
  • Sanjay Sharma
    Ophthalmology, Queen's University, Kingston, Ontario, Canada
  • Footnotes
    Commercial Relationships   Sarah Alowedi None; Patrick Wang None; Yao Wang None; Evan Sharma None; Sanjay Sharma None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3035. doi:
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    • Get Citation

      Sarah Alowedi, Patrick Wang, Yao Wang, Evan F Sharma, Sanjay Sharma; Immediate effects of e-cigarette use on systemic cardiovascular outcomes and retinal perfusion as measured by OCT angiography: a pilot study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3035.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this prospective cross-sectional study is to evaluate systemic cardiovascular outcomes and retinal perfusion immediately following e-cigarette use (vaping) as assessed by optical coherence tomography angiography (OCT-A).

Methods : Thirteen healthy volunteers (26 eyes) with no known history of any systemic or ocular disease were included in the study. Each participant was asked to abstain from vaping for at least one hour before baseline OCT-A. Participants were asked to vape from a disposable vaping pod device loaded with 1.2 mL of SaltNic e-liquid (concentrated salt-based nicotine) with 6% nicotine by volume under supervision. Each participant was instructed to inhale 15 doses over a 10-minute period. OCT-A scans (AngioPlex Metrix) were taken before and after vaping. The optic nerve and macula of both eyes were imaged at each timepoint with a 3×3mm scan. The superficial and deep retinal plexus were quantified at both time intervals. Systemic blood pressure and heart rate measurements were also measured before and immediately after vaping.

Results : The age of our subjects ranged from 18 to 23 years (mean +/- SD, 24.6 +/- 1.20). The ratio of men to women was 2:3. We observed a significant increase in heart rate after vaping HR=79.9 vs. 87 (p = 0.0105). We also observed a significant increase in diastolic BP = 67.1 mmHg vs. 71.5 mmHg (p = 0.03). The average size of the foveal avascular zone (FAZ) did not change significantly (p > 0.05) before (0.19) and after vaping (0.17). There were also no significant immediate changes seen in full macular vascular density before (18.48) and after (17.75). We noticed a trend whereby a decrease in deep capillary plexus flow was noted following e-cigarette use (vaping reduced flow by 4.9%; P= 0.21, power= 43%).

Conclusions : Our study demonstrated a clear systemic effect of e-cigarette use on the systemic vascular system of our healthy volunteers, as both heart rate and BP increased after exposure. We also noted a trend towards a reduction in flow of the deep capillary bed (mean reduction in flow of 4.9%). This effect was not statistically significant given the small size of our pilot study (power=43%). We plan to continue recruiting additional healthy volunteers to further evaluate the effects of e-cigarette use on the retinal vasculature.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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