Investigative Ophthalmology & Visual Science Cover Image for Volume 64, Issue 8
June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Impact of anti-optic nerve antibodies in patients with autoimmune retinopathy
Prapatsorn Ongpalakorn; SungWho Park; Chris Or; Amir Akhavanrezayat; Irmak Karaca; Albert John Bromeo; Azadeh Mobasserian; Cigdem Yasar; Negin Yavari; Gunay Uludag; Ngoc Than; YongUn Shin; Anh Ngoc Tram Tran; Vahid Bazojoo; Diana V Do; Quan Dong Nguyen
Author Affiliations & Notes
  • Prapatsorn Ongpalakorn
    Byers Eye Institute, Stanford University, Stanford, California, United States
    Ophthalmology Department, Nopparat Rajathanee Hospital, Bangkok, Bangkok, Thailand
  • SungWho Park
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Chris Or
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Amir Akhavanrezayat
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Irmak Karaca
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Albert John Bromeo
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Azadeh Mobasserian
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Cigdem Yasar
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Negin Yavari
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Gunay Uludag
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Ngoc Than
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • YongUn Shin
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Anh Ngoc Tram Tran
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Vahid Bazojoo
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Diana V Do
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Quan Dong Nguyen
    Byers Eye Institute, Stanford University, Stanford, California, United States
  • Footnotes
    Commercial Relationships   Prapatsorn Ongpalakorn None; SungWho Park None; Chris Or None; Amir Akhavanrezayat None; Irmak Karaca None; Albert John Bromeo None; Azadeh Mobasserian None; Cigdem Yasar None; Negin Yavari None; Gunay Uludag None; Ngoc Than None; YongUn Shin None; Anh Tran None; Vahid Bazojoo None; Diana Do Allergan, Genentech, Kriya, Regeneron, Code C (Consultant/Contractor), Kodiak, Code I (Personal Financial Interest); Quan Nguyen Belite Bio, Genentech, Kriya, Regeneron, Rezolute, Code C (Consultant/Contractor)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3917. doi:
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      Prapatsorn Ongpalakorn, SungWho Park, Chris Or, Amir Akhavanrezayat, Irmak Karaca, Albert John Bromeo, Azadeh Mobasserian, Cigdem Yasar, Negin Yavari, Gunay Uludag, Ngoc Than, YongUn Shin, Anh Ngoc Tram Tran, Vahid Bazojoo, Diana V Do, Quan Dong Nguyen; Impact of anti-optic nerve antibodies in patients with autoimmune retinopathy. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3917.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Given the challenging diagnosis of autoimmune retinopathy (AIR), blood tests serve as beneficial diagnostic value. In this retrospective observational case series, we investigated the correlation between the presence of anti-optic nerve antibodies (AOA) and clinical findings in patients with AIR.

Methods : Medical records of patients who were diagnosed with AIR [based on the presence of antiretinal antibodies (ARA)] from January 2017 to October 2022 were retrospectively reviewed. All patients also underwent testing for AOA. The patients were then further analyzed in two groups (positive AOA and negative AOA). Visual acuity, optic disc leakage in fluorescein angiography (FA), and visual evoked potential (VEP) were compared between the two groups.

Results : A total of 25 patients (50 eyes) were included, of which 76% (19 patients, 38 eyes) were positive for AOA. There was no statistically significant difference between the patients with positive and negative AOA in terms of age [51.22±22.79 (range, 7.7-86.9) vs. 36.85±20.43 (range, 9.3-66.7), p=0.238)], visual acuity (LogMAR 0.65±0.75 vs LogMAR 0.33±0.63, p=0.129), and baseline VEP P100 [60 min 125.60 ±15.30 (range, 103.00-153.00 ms); 15 min 128.60±15.50 (range, 101.50-151.50 ms) vs. 60 min 131.41±27.99 (range, 109.50-194.00 ms); 15 min 124.30±15.73 (range, 106.00-158.50 ms), p=0.928 and 0.347, respectively]. Optic disc swelling was not detected in any subject. Two of the 38 eyes (5.26%) in the positive AOA group had optic disc leakage in FA, compared to two of the 12 eyes (16.67%) in the negative AOA group (p=0.240).

Conclusions : The majority of patients with AIR had positive AOA. There was no significant difference in terms of baseline clinical findings and function of the optic nerve of AIR patients with positive or negative AOA. However, longitudinal impact of the presence of AOA needs to be assessed.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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