Abstract
Presentation Description :
Pulsatile erythrocyte flow in human retinal capillaries reflects a fundamental functioning aspect of retinal microcirculation. Inside the capillary, the erythrocytes are continuously accelerated and decelerated by systemic pressure and hydrostatic and osmotic pressures periodically with the heartbeat. This process can be described by the Navier-Stokes equation: ρ(∂v/∂t + v●▽v) = - ▽P+ ▽●T, where ρ is the density, v is the velocity, P is the pressure, and T represents the stress tensor. The time variation of the flow velocity ∂v/∂t, i.e., the acceleration, is a higher-order dynamics term (compared to velocity) of the pulsatile flow, reflects the temporal variation of the hemodynamic forces, and informs the dynamic mechanical properties of the erythrocyte-capillary system. Higher-order dynamics relating to the acceleration of the erythrocytes in retinal capillaries have not been investigated in the human eye due to inadequate technical measures. This study aims to characterize the higher-order retinal hemodynamics and identify sensitive biomarkers for quantifying age-related changes in the retinal microcirculation using high-speed adaptive optics near-confocal ophthalmoscopy. In human subjects with normal physical health at different ages, we demonstrate that higher-order hemodynamic characteristics of the erythrocyte flow in the retinal capillary can disclose age-related differences in the retinal microcirculation.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.