Abstract
Purpose :
This study analyzed pretreatment factors related to vision loss after successful photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).
Methods :
This was a retrospective case-control study. Eighty-five eyes with CSC, who are treated by PDT and whose subretinal fluid resolves within six months, were divided into two groups: those with vision loss (VL) after PDT (best-corrected visual acuity [BCVA] six months post-PDT was worse than baseline), and the remaining eyes (vision maintained or improved [VMI] after PDT). We explored the VL group's characteristics from pretreatment factors, and the clinical diagnostic potentials of the factors identified were also examined.
Results :
Seventeen eyes were in the VL group, and 68 were in the VMI group. The factors related to the VL group were the thickness from the internal limiting membrane to the external limiting membrane (IET) (P < 0.001, Mann-Whitney U test), the thickness from the external limiting membrane to the photoreceptor outer segment layer (EOT) (P = 0.041), the neurosensory retinal thickness (NSRT) (P < 0.001). In terms of clinical diagnostics, the highest sensitivity was from IET, EOT, and NSRT (94.1%), the highest specificity was from IET (51.5%), the highest positive predictive value was from IET (32.7%), and the highest negative predictive value was from IET (97.2% ) when we use the maximum values except for outliers of those as the cutoff values.
Conclusions :
The pretreatment retinal layer thickness can accurately predict visual loss after successful PDT. We could use these values as reference criteria for treatment Initiation for CSC.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.