June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Compositional changes of gut microbiota in patients with Behcet’s disease: systematic literature review
Author Affiliations & Notes
  • GAHEE HAN
    Ophthalmology, Ajou University, Suwon, Gyeonggi-do, Korea (the Republic of)
  • DAEHWAN KWON
    Ophthalmology, Ajou University, Suwon, Gyeonggi-do, Korea (the Republic of)
  • WONBONG JANG
    Ophthalmology, Ajou University, Suwon, Gyeonggi-do, Korea (the Republic of)
  • Ji Hun Song
    Ophthalmology, Ajou University, Suwon, Gyeonggi-do, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   GAHEE HAN None; DAEHWAN KWON None; WONBONG JANG None; Ji Hun Song None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3581. doi:
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      GAHEE HAN, DAEHWAN KWON, WONBONG JANG, Ji Hun Song; Compositional changes of gut microbiota in patients with Behcet’s disease: systematic literature review. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3581.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Behcet’s disease(BD) is a systemic inflammatory disease characterized by recurrent attacks of oral aphthosis, genital ulcers, skin lesions, and uveitis. The gut microbiota is an active component of the immune system and plays an important role in maintaining homeostasis of the host immunity. We performed a comprehensive systematic review of the microbiome dysbiosis in patients with BD to compare with studies on gut microbiome dysbiosis between patients with BD and healthy control groups.

Methods : This systematic review was conducted using three major electronic databases (PubMed, EMBASE, and Cochrane Library) to identify potentially relevant published articles. All included articles met the following criteria; (1) participants diagnosed with BD, (2) analyzed the fecal samples, (3) samples analyzed by 16S rRNA gene sequencing or other methods to identify compromised microbial species, and (4) Abstract and Title were published in English.

Results : A total of 204 articles were identified in a systematic literature search of Pubmed, Cochrane Library, and EMBASE. Seven eligible studies were included in this systematic review. All studies analyzed fecal samples using 16S rRNA sequencing. Some compositional changes of gut microbiome were observed in patients with BD. At the genus level, two genera (Eggerthella, Bifidobacterium) were abundant in patients with BD and three genera (Phascolarctobacterium, Megamonas, Bacteroides) were more abundant in healthy controls than patients with BD.

Conclusions : The compositional alterations in the gut microbiome were associated with skewed immune responses and the emergence of self-reactive helper T cells. Three genera of bacteria abundant in the healthy groups were butyrate-producing bacteria, and two genera abundant in patients with BD were lactate-producing bacteria. In a healthy gut environment, there are abundant butyrate-producing bacteria that use dietary carbohydrates, including lactate and succinate. Since butyrate-producing bacteria using dietary carbohydrate substrates were lacking, the abundance of lactate-producing bacteria and pH in the gut environment were altered in patients with BD. This dysbiosis of the gut microbiome affects immunological homeostasis in the host.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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