Abstract
Purpose :
To evaluate the clinical performance of two commercially available daily disposable soft contact lenses (SCLs), verofilcon A and nesofilcon A.
Methods :
A prospective, randomized, controlled, double-masked, bilateral, crossover, daily wear, multicenter study was conducted in the US (Jan-Mar 2022). Subjects aged ≥18 years with non-diseased eyes requiring vision correction in the spherical power range of -1.00 D to -6.00 D were included. Subjects needed to be successful wearers of spherical SCLs over past 3 months for ≥5 days/week and ≥10 hours/day. Eligible subjects were randomized (1:1; single crossover) to wear verofilcon A or nesofilcon A SCLs bilaterally for ≥10 hours/day for 8-11 days, and attended 3 visits. On the day prior to visits 2 and 3, subjects were asked to wear study SCLs for ≥16 hours and complete take-home questionnaires. Primary endpoint: distance visual acuity (VA; log MAR) at week 1 (non-inferiority margin: 0.05). Other endpoints: subjective ratings (visual analog scale: 0 to 100) for comfort, vision and overall impression at 16 hours; and lens movement (-2=unacceptably tight to +2=unacceptably loose) and position (0=optimal lens centration to 2=unacceptable decentration) at week 1.
Results :
In total, 126 subjects completed the study (mean±SD age: 32.4±7.8 years; female: 66.7%). At week 1, verofilcon A was noninferior to nesofilcon A for distance VA (mean±SD logMAR: -0.13±0.08 vs -0.13±0.07; 95% UCL of LSM difference: 0.00). Verofilcon A had significantly higher ratings than nesofilcon A for comfort (77.9±18.7 vs 63.7±26.8), vision (84.1±15.6 vs 76.4±21.4) and overall impression (80.5±17.3 vs 68.9±24.9) at 16 hours (all p≤0.0001). All lenses had optimal/acceptable fit (in both primary and peripheral gazes) and optimal centration/acceptable decentration at week 1.
Conclusions :
Verofilcon A SCL was noninferior to nesofilcon A for distance visual acuity at week 1. Verofilcon A had higher subjective ratings than nesofilcon A SCLs for comfort, vision, and overall impression even after long hours of wear (16 hours of wear). All lenses had optimal movement and position at week 1.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.